{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T10:52:47Z","timestamp":1781088767734,"version":"3.54.1"},"reference-count":15,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"published-print":{"date-parts":[[2005]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Daivobet&lt;sup&gt;\u00ae&lt;\/sup&gt; is a once-daily treatment of psoriasis vulgaris containing betamethasone dipropionate and calcipotriol in a new ointment vehicle. &lt;i&gt;Objective:&lt;\/i&gt; To assess the cost-effectiveness of once-daily treatment with Daivobet (4 weeks) followed by calcipotriol (4 weeks) compared to tacalcitol (8 weeks). &lt;i&gt;Methods:&lt;\/i&gt; Resource utilization was assessed within a double-blind 8-week clinical trial (all treatments for psoriasis, adverse events and concomitant dermatological medication), estimated from the French societal perspective. &lt;i&gt;Results:&lt;\/i&gt; Total direct medical costs for psoriasis were comparable (Daivobet: EUR 107.53 and tacalcitol EUR 113.50) despite a higher acquisition cost for Daivobet. The probability of \u226775% reduction in the Psoriasis Area and Severity Index (effectiveness criterion) was 46.6% with Daivobet and 13.9% with tacalcitol at 4 weeks, and 44.6 and 23.8%, respectively, at 8 weeks (both: p &lt; 0.001). Over 8 weeks, Daivobet was almost twice as cost-effective as tacalcitol (EUR 241.22 per successful treatment vs. EUR 476.70); this result was robust to sensitivity assumptions. &lt;i&gt;Conclusion:&lt;\/i&gt; Daivobet is more effective and less costly than tacalcitol for treating psoriasis.<\/jats:p>","DOI":"10.1159\/000086444","type":"journal-article","created":{"date-parts":[[2005,8,5]],"date-time":"2005-08-05T12:17:04Z","timestamp":1123244224000},"page":"139-145","source":"Crossref","is-referenced-by-count":24,"title":["Cost-Effectiveness of Once-Daily Treatment with Calcipotriol\/Betamethasone Dipropionate Followed by Calcipotriol Alone Compared with Tacalcitol in the Treatment of Psoriasis vulgaris"],"prefix":"10.1159","volume":"211","author":[{"given":"Pascale","family":"Peeters","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Paul","family":"Ortonne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren\u00e9","family":"Sitbon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Guignard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2005,8,18]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2230.2001.00832.x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM199503023320907"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2FS0926-9959%2897%2900138-4"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1080%2F00015550152384254"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2133.1998.02461.x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.3109%2F09546639709160505"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1159%2F000071788"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1067%2Fmjd.2003.130"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1159%2F000080854"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1136%2Fbmj.320.7240.963"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2FS0190-9622%2898%2970171-9"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1080%2F00015550252948194"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2133.2002.04967.x"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016%2FS0190-9622%2899%2970301-4"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1159%2F000017972"}],"container-title":["Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/86444","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/86444","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:12:18Z","timestamp":1745464338000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000086444"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005]]},"references-count":15,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2005,8,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000086444","archive":["Portico"],"relation":{},"ISSN":["1018-8665","1421-9832"],"issn-type":[{"value":"1018-8665","type":"print"},{"value":"1421-9832","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005]]}}}