{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T07:31:15Z","timestamp":1762673475678,"version":"3.40.4"},"reference-count":24,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ophthalmic Res"],"published-print":{"date-parts":[[2005]]},"abstract":"<jats:p>To clarify the potential role of endothelin-1 (ET-1) in the pathogenesis of glaucoma, the endothelin receptors expressed in bovine trabecular meshwork (TM) and ciliary muscle (CM) were identified. TM and CM strips were subjected to ET-1 as well as to specific endothelin receptor antagonists. In both tissues BQ123, a specific ET-A receptor antagonist, substantially inhibited ET-1-induced contraction. BQ788, a specific ET-B receptor antagonist, showed only moderate effects. Both ET receptor types were detected in bovine TM and CM using Western blot analysis. ET-1 produced an increase in intracellular calcium in cultured TM cells. This effect was inhibited by BQ123, but not by BQ788. Thus, although both receptors are present, the ET-A receptor appears to play the predominant role in mediating contraction in both the TM and CM, while the ET-B receptor seems to contribute little to the overall ET-1 effect.<\/jats:p>","DOI":"10.1159\/000086471","type":"journal-article","created":{"date-parts":[[2005,6,22]],"date-time":"2005-06-22T12:20:27Z","timestamp":1119442827000},"page":"179-187","source":"Crossref","is-referenced-by-count":15,"title":["Pharmacological and Functional Characterization of Endothelin Receptors in Bovine Trabecular Meshwork and Ciliary Muscle"],"prefix":"10.1159","volume":"37","author":[{"given":"Lars","family":"Choritz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rita","family":"Rosenthal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Fromm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael H.","family":"Foerster","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hagen","family":"Thieme","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2005,7,29]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1038%2F332411a0"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2F0165-6147%2892%2990038-8"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1124%2Fpr.54.2.219"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1023%2FA%3A1026005418874"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2FS0039-6257%2805%2980073-6"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2004.01.071"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1097%2F00061198-200206000-00016"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1007%2FBF00947082"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1136%2Fbjo.2003.028290"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2FS0014-4835%2805%2980042-9"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1034%2Fj.1600-0420.1998.760605.x"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1159%2F000157397"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2FS1350-9462%2899%2900015-4"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016%2F0014-4835%2891%2990141-Z"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.3109%2F02713689109020335"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016%2FS1350-9462%2898%2900011-1"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1159%2F000310783"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1007%2Fs004170100288"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.86.8.2863"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016%2FS0014-4835%2805%2980049-1"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1172%2FJCI116338"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016%2F0163-7258%2895%2902015-2"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1006%2Ffrne.1996.0009"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1007%2FBF00227908"}],"container-title":["Ophthalmic Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/86471","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/86471","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:12:43Z","timestamp":1745464363000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000086471"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005]]},"references-count":24,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2005,8,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000086471","archive":["Portico"],"relation":{},"ISSN":["0030-3747","1423-0259"],"issn-type":[{"type":"print","value":"0030-3747"},{"type":"electronic","value":"1423-0259"}],"subject":[],"published":{"date-parts":[[2005]]}}}