{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T09:12:50Z","timestamp":1778749970678,"version":"3.51.4"},"reference-count":34,"publisher":"Elsevier BV","issue":"4-5","license":[{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pancreatology"],"published-print":{"date-parts":[[2005,1]]},"DOI":"10.1159\/000086537","type":"journal-article","created":{"date-parts":[[2005,6,24]],"date-time":"2005-06-24T08:57:06Z","timestamp":1119603426000},"page":"370-379","source":"Crossref","is-referenced-by-count":53,"title":["Gene expression analysis of pancreatic cell lines reveals genes overexpressed in pancreatic cancer"],"prefix":"10.1016","volume":"5","author":[{"given":"Ingo","family":"Alldinger","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dag","family":"Dittert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Peiper","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Fusco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gennaro","family":"Chiappetta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eike","family":"Staub","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"L\u00f6hr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ralf","family":"Jesnowski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gustavo","family":"Baretton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Detlef","family":"Ockert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans-Detlev","family":"Saeger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Gr\u00fctzmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Pilarsky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1159\/000086537_bib1","doi-asserted-by":"crossref","first-page":"5","DOI":"10.3322\/canjclin.53.1.5","article-title":"Cancer statistics","volume":"53","author":"Jemal","year":"2003","journal-title":"CA Cancer J Clin"},{"key":"10.1159\/000086537_bib2","series-title":"Zusammenarbeit mit dem Robert Koch Institut","article-title":"Haufigkeiten und Trends","year":"1999"},{"key":"10.1159\/000086537_bib3","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1097\/00000658-200112000-00008","article-title":"Identification of diseasespecific genes in chronic pancreatitis using DNA array technology","volume":"234","author":"Friess","year":"2002","journal-title":"Ann Surg"},{"key":"10.1159\/000086537_bib4","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S0168-1656(00)00204-2","article-title":"The application of DNA microar-rays in gene expression analysis","volume":"78","author":"van Hal","year":"2000","journal-title":"J Biotechnol"},{"key":"10.1159\/000086537_bib5","first-page":"2890","article-title":"Identification of differentially expressed genes in pancreatic cancer cells using cDNA microarray","volume":"62","author":"Han","year":"2002","journal-title":"Cancer Res"},{"key":"10.1159\/000086537_bib6","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1016\/S0002-9440(10)62551-5","article-title":"Discovery of novel tumor markers of pancreatic cancer using global gene expression technology","volume":"160","author":"Iacobuzio-Donahue","year":"2002","journal-title":"Am J Pathol"},{"key":"10.1159\/000086537_bib7","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1016\/S0002-9440(10)63911-9","article-title":"Exploration of global gene expression patterns in pancreatic adenocarcinoma using cDNA mi-croarrays","volume":"162","author":"Iacobuzio-Donahue","year":"2003","journal-title":"Am J Pathol"},{"key":"10.1159\/000086537_bib8","first-page":"291","article-title":"Biological and molecular characterization of a new human ampullary cancer cell line","volume":"23","author":"Peiper","year":"2003","journal-title":"Anticancer Res"},{"key":"10.1159\/000086537_bib9","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1111\/j.1749-6632.1999.tb09509.x","article-title":"Immortalized pancreatic duct cells in vitro and in vivo","volume":"880","author":"Jesnowski","year":"1999","journal-title":"Ann NY Acad Sci"},{"key":"10.1159\/000086537_bib10","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1159\/000070087","article-title":"Systematic isolation of genes differentially expressed in normal and cancerous tissue of the pancreas","volume":"3","author":"Grutzmann","year":"2003","journal-title":"Pancreatology"},{"key":"10.1159\/000086537_bib11","doi-asserted-by":"crossref","first-page":"4251","DOI":"10.1093\/nar\/27.21.4251","article-title":"Exhaustive mining of EST libraries for genes differentially expressed in normal and tumour tissues","volume":"27","author":"Schmitt","year":"1999","journal-title":"Nucleic Acids Res"},{"key":"10.1159\/000086537_bib12","doi-asserted-by":"crossref","first-page":"e15","DOI":"10.1093\/nar\/gng015","article-title":"Summaries of Affymetrix GeneChip probe level data","volume":"31","author":"Irizarry","year":"2003","journal-title":"Nucleic Acids Res"},{"key":"10.1159\/000086537_bib13","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/S0002-9440(10)65178-4","article-title":"Thymosin beta-10 gene overexpression is a general event in human carcinogenesis","volume":"155","author":"Santelli","year":"1999","journal-title":"Am J Pathol"},{"key":"10.1159\/000086537_bib14","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/S0002-9440(10)65298-4","article-title":"Specific chromosomal aberration and amplification of the AIB1 nuclear receptor coactivator gene in pancreatic carcinomas","volume":"154","author":"Ghadimi","year":"1999","journal-title":"Am J Pathol"},{"key":"10.1159\/000086537_bib15","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1007\/s00428-003-0884-1","article-title":"Gene expression profiles of microdissected pancreatic ductal adenocarcinoma","volume":"443","author":"Grutzmann","year":"2003","journal-title":"Virchows Arch"},{"key":"10.1159\/000086537_bib16","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1038\/32433","article-title":"A causal role for E-cadherin in the transition from adenoma to carcinoma","volume":"392","author":"Perl","year":"1998","journal-title":"Nature"},{"key":"10.1159\/000086537_bib17","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1002\/(SICI)1098-1004(1998)12:4<226::AID-HUMU2>3.0.CO;2-D","article-title":"Mutations of the human E-cadherin (CDH1) gene","volume":"12","author":"Berx","year":"1998","journal-title":"Hum Mutat"},{"key":"10.1159\/000086537_bib18","doi-asserted-by":"crossref","first-page":"6107","DOI":"10.1002\/j.1460-2075.1995.tb00301.x","article-title":"E-cadherin is a tumour\/invasion suppressor gene mutated in human lobular breast cancers","volume":"14","author":"Berx","year":"1995","journal-title":"EMBO J"},{"key":"10.1159\/000086537_bib19","first-page":"4945","article-title":"SER-PINE2 (protease nexin I) promotes extracellular matrix production and local invasion of pancreatic tumors in vivo","volume":"63","author":"Buchholz","year":"2003","journal-title":"Cancer Res"},{"key":"10.1159\/000086537_bib20","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1007\/s00428-003-0784-4","article-title":"A comprehensive characterization of pancreatic ductal carcinoma cell lines: Towards the establishment of an in vitro research platform","volume":"442","author":"Sipos","year":"2003","journal-title":"Virchows Arch"},{"key":"10.1159\/000086537_bib21","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1530\/eje.0.1400597","article-title":"Regulation of thymosin beta10 expression by TSH and other mitogenic signals in the thyroid gland and in cultured thyrocytes","volume":"140","author":"Viglietto","year":"1999","journal-title":"Eur J Endocrinol"},{"key":"10.1159\/000086537_bib22","doi-asserted-by":"crossref","first-page":"6700","DOI":"10.1038\/sj.onc.1204683","article-title":"Overexpression of the thymosin beta-10 gene in human ovarian cancer cells disrupts F-actin stress fiber and leads to apoptosis","volume":"20","author":"Lee","year":"2001","journal-title":"Oncogene"},{"key":"10.1159\/000086537_bib23","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1089\/105072502760339325","article-title":"Thymosin beta-10 protein synthesis suppression reduces the growth of human thyroid carcinoma cells in semisolid medium","volume":"12","author":"Santelli","year":"2002","journal-title":"Thyroid"},{"key":"10.1159\/000086537_bib24","first-page":"4602","article-title":"Identification of 5-fluorouracil-inducible target genes using cDNA microarray profiling","volume":"63","author":"Maxwell","year":"2003","journal-title":"Cancer Res"},{"key":"10.1159\/000086537_bib25","first-page":"863","article-title":"Prefoldin, a chaperone that delivers unfolded proteins to cytosolic chaperonin","volume":"93","author":"Ampe","year":"1998","journal-title":"Cell Calcium"},{"key":"10.1159\/000086537_bib26","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S1570-9639(02)00449-1","article-title":"Regulation of calmodulin mRNAs in differentiating human IMR-32 neuroblastoma cells","volume":"1600","author":"Toutenhoofd","year":"2002","journal-title":"Biochim Biophys Acta"},{"key":"10.1159\/000086537_bib27","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1023\/A:1021644918117","article-title":"CSE1L\/CAS: Its role in proliferation and apoptosis","volume":"8","author":"Behrens","year":"2003","journal-title":"Apoptosis"},{"key":"10.1159\/000086537_bib28","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1002\/(SICI)1097-4644(2000)77:34+<61::AID-JCB11>3.0.CO;2-S","article-title":"Differential expression of genes by tumor cells of a low or a high malignancy phenotype: The case of murine and human Ly-6 proteins","volume":"34","author":"Witz","year":"2000","journal-title":"J Cell Biochem Suppl"},{"key":"10.1159\/000086537_bib29","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1126\/science.7652577","article-title":"A p16INK4a-insensitive CDK4 mutant targeted by cytolytic T lymphocytes in a human melanoma","volume":"269","author":"Wolfel","year":"1995","journal-title":"Science"},{"key":"10.1159\/000086537_bib30","first-page":"1053","article-title":"ADAM9 is a independent prognostic parameter of pancreatic ductal adenocarcinoma survival","volume":"90","author":"Grutzmann","year":"2004","journal-title":"Br J Cancer"},{"key":"10.1159\/000086537_bib31","first-page":"1643","article-title":"The human prohibitin gene located on chromosome 17q21 is mutated in sporadic breast cancer","volume":"52","author":"Sato","year":"1992","journal-title":"Cancer Res"},{"key":"10.1159\/000086537_bib32","first-page":"333","article-title":"Cyclindependent kinase-inhibitor 1 (CDKN1A) in the squamous epithelium of the oropharynx: Possible implications of molecular biology and compartmentation","volume":"21","author":"Wagner","year":"2001","journal-title":"Anticancer Res"},{"key":"10.1159\/000086537_bib33","first-page":"3508","article-title":"Downregulation of E-cadherin expression by collagen type I and type III in pancreatic cancer cell lines","volume":"61","author":"Menke","year":"2001","journal-title":"Cancer Res"},{"key":"10.1159\/000086537_bib34","first-page":"3845","article-title":"E-cadherin gene mutations provide clues to diffuse type gastric carcinomas","volume":"54","author":"Becker","year":"1994","journal-title":"Cancer Res"}],"container-title":["Pancreatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1424390305800109?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1424390305800109?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,4,7]],"date-time":"2020-04-07T22:41:54Z","timestamp":1586299314000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1424390305800109"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,1]]},"references-count":34,"journal-issue":{"issue":"4-5","published-print":{"date-parts":[[2005,1]]}},"alternative-id":["S1424390305800109"],"URL":"https:\/\/doi.org\/10.1159\/000086537","relation":{},"ISSN":["1424-3903"],"issn-type":[{"value":"1424-3903","type":"print"}],"subject":[],"published":{"date-parts":[[2005,1]]}}}