{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:24:53Z","timestamp":1791894293840,"version":"4.3.4"},"reference-count":14,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Blood Purif"],"published-print":{"date-parts":[[2005]]},"abstract":"<jats:p>&lt;i&gt;Background\/Aims:&lt;\/i&gt; Prometheus&lt;sup&gt;\u00ae&lt;\/sup&gt; is a newly developed extracorporeal liver support system that combines removal of albumin-bound substances (adsorption on resin adsorbers) and water-soluble substances (diffusion during high-flux hemodialysis). Therefore, it is a promising treatment option for patients with hepatorenal syndrome (HRS). &lt;i&gt;Methods:&lt;\/i&gt; We studied 10 patients with HRS in a prospective clinical study. All patients underwent 2 consecutive Prometheus treatments. A variety of clinical and biochemical parameters were assessed. &lt;i&gt;Results:&lt;\/i&gt; Prometheus treatment was uncomplicated and safe. A statistically significant improvement of serum creatinine and urea concentrations as well as blood pH was observed after Prometheus treatment. Furthermore, liver detoxification was supported by a significant decrease of serum levels of conjugated bilirubin, bile acids and ammonia. &lt;i&gt;Conclusions:&lt;\/i&gt; Prometheus is a safe treatment for patients with HRS. Both, albumin-bound and water-soluble substances were effectively removed. Controlled studies will evaluate the effect of this new treatment option on survival in patients with HRS.<\/jats:p>","DOI":"10.1159\/000086552","type":"journal-article","created":{"date-parts":[[2005,6,24]],"date-time":"2005-06-24T08:57:06Z","timestamp":1119603426000},"page":"298-302","source":"Crossref","is-referenced-by-count":63,"title":["The Prometheus&lt;sup&gt;\u00ae&lt;\/sup&gt; Device for Extracorporeal Support of Combined Liver and Renal Failure"],"prefix":"10.1159","volume":"23","author":[{"given":"Kinan","family":"Rifai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Ernst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"Kretschmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carsten","family":"Hafer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hermann","family":"Haller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael Peter","family":"Manns","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danilo","family":"Fliser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2005,10,4]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1053%2Fjhep.2003.50084"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002%2Fhep.510230122"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1525-1594.1999.06292.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2803%2914903-3"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2FS0168-8278%2898%2980151-7"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1023%2FA%3A1021763221337"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1053%2Fjhep.2001.22172"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1159%2F000047017"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1097%2F00002480-199307000-00097"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1525-1594.2002.06822.x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1053%2Flv.2000.6355"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1159%2F000083941"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2FS0168-8278%2803%2900468-9"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1001%2Fjama.289.2.217"}],"container-title":["Blood Purification"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/86552","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/86552","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:13:05Z","timestamp":1745464385000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000086552"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005]]},"references-count":14,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2005,9,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000086552","archive":["Portico"],"relation":{},"ISSN":["0253-5068","1421-9735"],"issn-type":[{"value":"0253-5068","type":"print"},{"value":"1421-9735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005]]}}}