{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T04:09:23Z","timestamp":1745554163899,"version":"3.40.4"},"reference-count":20,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathobiology"],"published-print":{"date-parts":[[2005]]},"abstract":"<i>Objectives:<\/i> The dysregulated overexpression of BCL10 that results from a specific chromosomal translocation t(1;14)(p22;q32) in mucosa-associated lymphoid tissue lymphoma has been shown to activate nuclear factor (NF)-\u0138B, which may promote growth and survival in tumor cells. Accordingly, the molecular mechanisms underlying NF-\u0138B activation may be responsible for lymphomagenesis. The aim of this study was to determine the molecular mechanisms underlying NF-\u0138B activation by BCL10 overexpression. <i>Methods:<\/i> HeLa or COS-1 cells were transfected with BCL10, intracellular localization of BCL10 and the activation of NF-\u0138B were analyzed. <i>Results:<\/i> BCL10 expressed at a high level exhibited a filamentous distribution at the perinuclear region, whereas BCL10 at a low level of expression displayed a diffuse cytoplasmic distribution. Furthermore, the BCL10-mediated NF-\u0138B activation was efficiently inhibited by a Ca<sup>2+<\/sup> chelating agent or a Ca<sup>2+<\/sup> channel blocker. We also found that amino acids (107\u2013119) of BCL10 are required for the formation of filamentous structures at the perinuclear region and NF-\u0138B activation. <i>Conclusion:<\/i> These findings suggest that the filamentous pattern of overexpressed BCL10 at the perinuclear region adjacent to the endoplasmic reticulum is important for the BCL10-mediated NF-\u0138B activation.<\/jats:p>","DOI":"10.1159\/000086789","type":"journal-article","created":{"date-parts":[[2005,8,30]],"date-time":"2005-08-30T12:24:58Z","timestamp":1125404698000},"page":"191-202","source":"Crossref","is-referenced-by-count":3,"title":["Accumulation of BCL10 at the Perinuclear Region is Required for the BCL10-Mediated Nuclear Factor-Kappa B Activation"],"prefix":"10.1159","volume":"72","author":[{"given":"Kyoko","family":"Nakamura","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takao","family":"Senda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenzo","family":"Sato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeo","family":"Mori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masatsugu","family":"Moriyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2005,9,2]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2FS0092-8674%2800%2980957-5"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1038%2F8767"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1074%2Fjbc.274.29.20127"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1074%2Fjbc.274.15.9955"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1074%2Fjbc.274.15.9962"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1074%2Fjbc.274.15.10287"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1083%2Fjcb.148.6.1131"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1074%2Fjbc.274.25.17946"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2FS0092-8674%2801%2900189-1"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1006%2Fbbrc.2001.5216"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.onc.1202334"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1007%2FBF00266757"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2FS0014-5793%2801%2902414-0"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1471-4159.2002.01059.x"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.cdd.4400632"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1083%2Fjcb.141.5.1255"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1074%2Fjbc.274.46.32975"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1146%2Fannurev.cb.04.110188.002415"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.onc.1203018"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1074%2Fjbc.M009984200"}],"container-title":["Pathobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/86789","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/86789","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:15:43Z","timestamp":1745464543000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000086789"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005]]},"references-count":20,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2005,9,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000086789","archive":["Portico"],"relation":{},"ISSN":["1015-2008","1423-0291"],"issn-type":[{"type":"print","value":"1015-2008"},{"type":"electronic","value":"1423-0291"}],"subject":[],"published":{"date-parts":[[2005]]}}}