{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T12:29:36Z","timestamp":1780921776799,"version":"3.54.1"},"reference-count":27,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"published-print":{"date-parts":[[2005]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Munro\u2019s microabscesses are a characteristic histopathologic feature of psoriasis vulgaris; however, the pathomechanisms underlying the migration of transepidermal leukocytes (PMNs) have not been fully elucidated yet. &lt;i&gt;Objective and Methods:&lt;\/i&gt; Since the lesional scale extracts contain potent chemoattractants, such as IL-8 and C5a fragments, we studied their location in the lesions of psoriasis vulgaris and PPP with immunohistochemical techniques. &lt;i&gt;Results:&lt;\/i&gt; Localization of IL-8 was not detected in the subcorneal keratinocytes but was demonstrated only in the basal keratinocytes together with migrating PMNs. In contrast, the presence of a complement fragment, C3b, was observed on the cell membranes of subcorneal keratinocytes, suggesting that these were the sites of complement activation. &lt;i&gt;Conclusion:&lt;\/i&gt; Such distinct localization of IL-8 and complement components suggests that the intraepidermal migration of PMNs takes place first according to the concentration gradient of IL-8, and thereafter they are guided by complement components to the final destination, the subcorneal portion of the lesional skin.<\/jats:p>","DOI":"10.1159\/000087019","type":"journal-article","created":{"date-parts":[[2005,10,10]],"date-time":"2005-10-10T13:31:15Z","timestamp":1128951075000},"page":"249-255","source":"Crossref","is-referenced-by-count":44,"title":["Localization of IL-8 and Complement Components in Lesional Skin of Psoriasis vulgaris and Pustulosis palmaris et plantaris"],"prefix":"10.1159","volume":"211","author":[{"given":"Maki","family":"Ozawa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadashi","family":"Terui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hachiro","family":"Tagami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2005,11,4]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1159%2F000248440"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1111%2F1523-1747.ep12558281"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1007%2FBF01112914"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111%2F1523-1747.ep12343916"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111%2F1523-1747.ep12371803"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111%2F1523-1747.ep12514689"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1080%2F000155599750011606"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111%2F1523-1747.ep12495817"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2FS0923-1811%2800%2900167-5"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1007%2FBF00373374"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1001%2Farchderm.129.1.74"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1083%2Fjcb.147.3.577"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111%2F1523-1747.ep12709634"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-4362.2001.01262.x"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1084%2Fjem.184.5.2007"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1159%2F000070942"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1111%2F1523-1747.ep12523566"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1523-1747.1998.00347.x"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1159%2F000078582"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1111%2F1523-1747.ep12478128"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1111%2F1523-1747.ep12481959"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1111%2F1523-1747.ep12484155"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1111%2F1523-1747.ep12514737"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1111%2F1523-1747.ep12612833"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1600-0625.1998.tb00316.x"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1111%2F1523-1747.ep12285633"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1523-1747.2000.00841.x"}],"container-title":["Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/87019","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/87019","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:17:53Z","timestamp":1745464673000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000087019"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005]]},"references-count":27,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2005,10,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000087019","archive":["Portico"],"relation":{},"ISSN":["1018-8665","1421-9832"],"issn-type":[{"value":"1018-8665","type":"print"},{"value":"1421-9832","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005]]}}}