{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T07:01:12Z","timestamp":1765609272407,"version":"3.40.4"},"reference-count":23,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Digestion"],"published-print":{"date-parts":[[2005]]},"abstract":"<jats:p>Background: Confirmation of Helicobacter pylori eradication by urea breath test (UBT) is currently performed 4\u20136 weeks after completion of therapy because of unacceptable false-negative results in UBTs performed earlier. Use of a high-dose citric acid test meal appears to enable accurate detection of H. pylori even during short term therapy with proton pump inhibitors. Aim: To evaluate if use of a high dose citric acid (4.0 g) test meal can decrease the interval required for confirmation of eradication after triple therapy. Methods: 233 patients positive for H. pylori were randomized to undergo UBT at 7 days or 14 days after triple therapy, and again at 6 weeks. The latter test was considered the gold standard test. Results: The UBT performed 6 weeks after the end of treatment found that 79.9% were cured. The same test 7 days after therapy found false-negative detection of H. pylori in 7.3% patients compared to 3.2% patients examined after 14 days. The sensitivity, specificity, positive and negative predictive values and accuracy for evaluation on day 14 were 80, 100, 100, 96.3 and 96.7%, respectively. Conclusions: High-dose citric acid-based UBT is a valid test for the assessment of H. pylori status 14 days after triple therapy. This may obviate the delay in instituting second-line eradication therapy, or further evaluation of the symptomatic patient unresponsive to therapy despite eradication.<\/jats:p>","DOI":"10.1159\/000087045","type":"journal-article","created":{"date-parts":[[2005,7,14]],"date-time":"2005-07-14T13:49:03Z","timestamp":1121348943000},"page":"208-212","source":"Crossref","is-referenced-by-count":14,"title":["Eradication of Helicobacter pylori Can Be Accurately Confirmed 14 Days after Termination of Triple Therapy Using a High-Dose Citric Acid-Based 13C Urea Breath Test"],"prefix":"10.1159","volume":"71","author":[{"given":"Haim","family":"Shirin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arie","family":"Levine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Orit","family":"Shevah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vered","family":"Shabat-Sehayek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hussein","family":"Aeed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joram","family":"Wardi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shlomo","family":"Birkenfeld","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rami","family":"Eliakim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yona","family":"Avni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2005,8,19]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1097%2F00042737-200012060-00009"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1136%2Fgut.45.2008.i18"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1572-0241.1999.01284.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2036.2002.01169.x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1523-5378.1997.tb00051.x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1572-0241.1998.00684.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1572-0241.2000.02005.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1523-5378.2003.00129.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1572-0241.2003.07426.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1023%2FA%3A1021931627698"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1440-1746.2003.02922.x"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1572-0241.1999.01069.x"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1572-0241.2001.03687.x"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1572-0241.2003.07187.x"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2036.2004.02021.x"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016%2FS0016-5085%2898%2970142-8"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016%2FS0016-5085%2898%2970633-X"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1136%2Fgut.52.7.933"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016%2FS0016-5085%2896%2970056-2"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2036.2000.00721.x"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1097%2F00042737-199809000-00006"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2036.2001.01096.x"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1572-0241.2002.05535.x"}],"container-title":["Digestion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/dig\/article-pdf\/71\/4\/208\/4032985\/000087045.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/dig\/article-pdf\/71\/4\/208\/4032985\/000087045.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:18:09Z","timestamp":1745464689000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000087045"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005]]},"references-count":23,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2005,8,1]]},"published-print":{"date-parts":[[2005,4,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000087045","archive":["Portico"],"relation":{},"ISSN":["0012-2823","1421-9867"],"issn-type":[{"type":"print","value":"0012-2823"},{"type":"electronic","value":"1421-9867"}],"subject":[],"published":{"date-parts":[[2005]]}}}