{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T22:15:48Z","timestamp":1792102548748,"version":"4.4.0"},"reference-count":24,"publisher":"S. Karger AG","issue":"2-3","license":[{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dement Geriatr Cogn Disord"],"published-print":{"date-parts":[[2005]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Several neuroimaging studies have shown reliable differences between Alzheimer\u2019s disease (AD) patients and age-matched controls. However, few studies have demonstrated the interactions between neuroimaging methods for the diagnoses of AD. &lt;i&gt;Objective:&lt;\/i&gt; In this study, we try to elucidate the complementary nature of magnetoencephalography (MEG) and magnetic resonance spectroscopy (MRS) examinations in the assessmentof AD. &lt;i&gt;Methods:&lt;\/i&gt; Ten patients fulfilling the NINCDS-ADRDA criteria of probable AD, and 10 elderly individuals with no history of neurological or psychiatric illness serving as age-matched controls participated in the study. All patients and controls received an MRS, MEG and neuropsychological assessment. MEG data were obtained in the context of a working memory task, previously utilized in a similar sample of patients. &lt;i&gt;Results:&lt;\/i&gt; The AD group showed a reduced number of activity sources over left temporoparietal areas during the late portion of the evoked magnetic field (between 400\u2013800 ms), as well as a bilateral temporoparietal increase in creatine and myoinositol concentrations, and in the myoinositol\/N-acetyl-aspartate ratio. The combination of the variables \u2018number of dipoles during the late portion of the evoked magnetic field\u2019 and \u2018myoinositol\/N-acetyl-aspartate ratio\u2019 accounted for 65% of the variance of the Mini Mental State Examination scores. &lt;i&gt;Conclusions:&lt;\/i&gt; These results highlight the importance of assessing the complex brain pathology underlying AD by utilizing multiple brain examination modalities in a coordinate approach.<\/jats:p>","DOI":"10.1159\/000087062","type":"journal-article","created":{"date-parts":[[2005,7,15]],"date-time":"2005-07-15T07:33:48Z","timestamp":1121412828000},"page":"145-152","source":"Crossref","is-referenced-by-count":16,"title":["Evidence of Biochemical and Biomagnetic Interactions in Alzheimer\u2019s Disease: An MEG and MR Spectroscopy Study"],"prefix":"10.1159","volume":"20","author":[{"given":"F.","family":"Maest\u00fa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Garc\u00eda-Segura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Ortiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Montoya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Gil-Gregorio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Campo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Via\u00f1o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Portera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2005,8,19]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2F0165-1781%2895%2902651-C"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1007%2FBF02252964"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002%2F1531-8249%28200004%2947%3A4%3C430%3A%3AAID-ANA5%3E3.0.CO%3B2-I"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2FS1388-2457%2800%2900427-2"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002%2Fana.410420114"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1749-6632.1997.tb48477.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1136%2Fjnnp.64.3.306"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1136%2Fjnnp.62.6.596"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2FS0006-3223%2802%2901366-5"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1097%2F00001756-200112210-00013"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1136%2Fjnnp.74.2.208"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1076%2Fjcen.20.5.706.1127"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1006%2Fnimg.2002.1235"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016%2FS1053-8119%2803%2900309-4"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1076%2Fjcen.21.4.465.883"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.2310%2F7010.2001.7010"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1002%2Fmrm.10332"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1001%2Farchpsyc.56.2.185"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2800%2902246-7"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016%2FS0730-725X%2898%2900168-4"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016%2FS1364-6613%2800%2901538-2"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016%2F0028-3932%2895%2900097-6"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1093%2Fcercor%2F11.1.1"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1159%2F000017133"}],"container-title":["Dementia 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