{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T14:54:01Z","timestamp":1791125641389,"version":"4.1.0"},"reference-count":9,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Res Paediatr"],"published-print":{"date-parts":[[2005]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; We report the health-related quality of life (QOL) of survivors of childhood cancer (acute lymphoblastic leukaemia, ALL, or central nervous system, CNS, tumour), and whether or not they had growth hormone deficiency (GHD) requiring growth hormone treatment (GHT). &lt;i&gt;Method:&lt;\/i&gt; We assessed 77 survivors of childhood ALL (n = 51) or CNS tumours (n = 26), aged between 8\u201318 years, and free from disease for \u22674 years. Survivors and their mothers independently rated survivors\u2019 QOL, and mothers completed semi-structured interviews to determine their views of the benefits and disadvantages of GHT. &lt;i&gt;Results:&lt;\/i&gt; Survivors, especially those treated for a CNS tumour, reported poorer QOL compared with UK population norms. Although survivors of ALL reported better QOL than survivors of CNS tumours, there were no differences depending on whether or not they were prescribed GHT. However, mothers reported that those prescribed GHT had worse QOL than those not. All but 2 survivors were responsible for their own injections. A minority of mothers were disappointed with the child\u2019s rate of growth, and reported that children experienced pain with injections. &lt;i&gt;Conclusion:&lt;\/i&gt; We conclude that QOL in survivors of childhood cancer is compromised compared with the normal population, especially following CNS tumours. Longitudinal studies are vital to determine whether GHT can contribute to improved QOL for cancer survivors, especially those who experience more intensive initial therapy regimes.<\/jats:p>","DOI":"10.1159\/000087066","type":"journal-article","created":{"date-parts":[[2005,7,15]],"date-time":"2005-07-15T07:33:48Z","timestamp":1121412828000},"page":"300-304","source":"Crossref","is-referenced-by-count":10,"title":["Growth Hormone Treatment and Quality of Life among Survivors of Childhood Cancer"],"prefix":"10.1159","volume":"63","author":[{"given":"C.","family":"Eiser","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.H.","family":"Vance","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Glaser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Galvin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Horne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Picton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Stoner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Butler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2005,8,10]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2265.1995.tb01909.x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1159%2F000184581"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1136%2Fadc.75.1.32"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.2004-0791"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2FS0959-8049%2801%2900046-6"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1136%2Fadc.70.6.472"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1007%2Fs004310050243"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1136%2Fadc.73.1.25"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1097%2F00005650-200108000-00006"}],"container-title":["Hormone Research in Paediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/87066","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/87066","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:18:36Z","timestamp":1745464716000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000087066"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005]]},"references-count":9,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2005,8,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000087066","archive":["Portico"],"relation":{},"ISSN":["1663-2818","1663-2826"],"issn-type":[{"value":"1663-2818","type":"print"},{"value":"1663-2826","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005]]}}}