{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T05:15:46Z","timestamp":1791090946692,"version":"4.1.0"},"reference-count":19,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Urol Int"],"published-print":{"date-parts":[[2005]]},"abstract":"<jats:p>&lt;i&gt;Purpose:&lt;\/i&gt; Treatment of interstitial cystitis is usually not successful in eradicating bladder pain and increased bladder capacity. This study was designed to evaluate the clinical effectiveness of suburothelial injection of botulinum A toxin in patients with chronic interstitial cystitis. &lt;i&gt;Methods:&lt;\/i&gt; Eight women and 2 men with chronic interstitial cystitis who had failed conventional treatments were enrolled in this study. In 5 patients, 100 units of botulinum A toxin was injected suburothelially into 20 sites, and an additional 100 units was injected into the trigone in the other 5 patients. Therapeutic outcome including functional bladder capacity, number of daily urinations, bladder pain, and urodynamic changes were compared between baseline and 3 months after treatment. &lt;i&gt;Results:&lt;\/i&gt; In 2 patients bladder pain and urinary frequency were improved 3 months after treatment. Mild difficulty in urination was reported by 7 patients. Functional bladder capacity recorded in a voiding diary was significantly increased (155 \u00b1 26.3 vs. 77 \u00b1 27.1 ml, p &lt; 0.001), and the frequency of daily urinations (18 \u00b1 7.7 vs. 24.2 \u00b1 10.3, p = 0.025) and the pain score (2.4 \u00b1 1.6 vs. 3.2 \u00b1 1.1, p = 0.003) were mildly but significantly reduced after treatment. Only the cystometric capacity improved significantly (287 \u00b1 115 vs. 210 \u00b1 63.8 ml, p = 0.05) in urodynamic results. Trigonal injection had no therapeutic effect on symptom or urodynamic improvement. No adverse effect was reported. &lt;i&gt;Conclusions:&lt;\/i&gt; The clinical result of suburothelial botulinum A toxin injection was disappointing. None of the patients was symptom free and only a limited improvement in bladder capacity and pain score was achieved in 2 patients.<\/jats:p>","DOI":"10.1159\/000087173","type":"journal-article","created":{"date-parts":[[2005,8,24]],"date-time":"2005-08-24T09:55:16Z","timestamp":1124877316000},"page":"170-174","source":"Crossref","is-referenced-by-count":82,"title":["Preliminary Results of Suburothelial Injection of Botulinum A Toxin in the Treatment of Chronic Interstitial Cystitis"],"prefix":"10.1159","volume":"75","author":[{"given":"Hann-Chorng","family":"Kuo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2008,7,9]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2FS0090-4295%2801%2901112-8"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1464-410X.1994.tb07634.x"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1097%2F00005392-200009010-00014"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2F0165-1838%2894%2990071-X"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1080%2F003655999750042187"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1007%2FBF01181533"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1038%2F35039519"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1464-410x.2001.02190.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1464-410X.2003.03802.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2FS0306-4522%2801%2900496-1"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.eururo.2003.12.004"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.urology.2003.12.007"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1023%2FA%3A1006903507321"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1464-410X.1992.tb15790.x"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1526-4610.43.7s.3.x"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1468-2982.2000.020004414.x"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1526-4610.2004.04007.x"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1002%2Fnau.10052"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1464-410x.2001.02190.x"}],"container-title":["Urologia Internationalis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/87173","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/87173","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:19:44Z","timestamp":1745464784000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000087173"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005]]},"references-count":19,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2005,9,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000087173","archive":["Portico"],"relation":{},"ISSN":["0042-1138","1423-0399"],"issn-type":[{"value":"0042-1138","type":"print"},{"value":"1423-0399","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005]]}}}