{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T18:21:49Z","timestamp":1790878909045,"version":"4.1.0"},"reference-count":13,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Blood Purif"],"published-print":{"date-parts":[[2005]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; In a previous study we demonstrated that mild metabolic alkalosis resulting from standard bicarbonate hemodialysis induces hypotension. This study aimed to compare hemodynamic consequences of either a decrease in the dialysate bicarbonate from 32 to 26 mmol\/l or an increase in the dialysate calcium of 0.25 mmol\/l and to verify whether the calcium shift secondary to alkalemia explains the consequences on blood pressure. &lt;i&gt;Methods:&lt;\/i&gt; In this randomized controlled trial with a single-blind, cross-over design, we used dialysis liquids with two different bicarbonate (32 mmol\/l in modalities A and C, and 26 mmol\/l in modality B) and calcium (1.25 mmol\/l in modalities A and B, and 1.50 mmol\/l in modality C) concentrations, and in 27 patients, 243 dialysis sessions, compared blood pressure, heart rate and the incidence of hypotension. &lt;i&gt;Results:&lt;\/i&gt; No significant differences were seen between A and B while an increase in systolic and diastolic blood pressures and a decrease in the incidence of hypotension (10.5 vs. 1.2%, p &lt; 0.05) were documented in C. The subgroup of patients who with A showed a lower mean systolic blood pressure received more angiotensin-converting enzyme inhibitors or angiotensin II type-1 receptor blockers (36 vs. 0%, p &lt;0.05) and in C showed a less important increase in systolic and diastolic pressures, but the incidence of hypotensive episodes between A and B was not significantly different (9.1 vs. 15.1%). &lt;i&gt;Conclusions:&lt;\/i&gt; In the present study it was not possible to demonstrate hemo dynamic instability associated with mild metabolic alkalosis. Even in the subgroup showing a lower blood pressure with a higher dialysate bicarbonate, significant hemodynamic or clinical consequences were not noticed. The calcium shift (0.05 mmol\/l) related to alkalemia would justify a mean decrease in systolic blood pressure of only about 1 mm Hg.<\/jats:p>","DOI":"10.1159\/000087193","type":"journal-article","created":{"date-parts":[[2005,7,29]],"date-time":"2005-07-29T10:02:17Z","timestamp":1122631337000},"page":"365-372","source":"Crossref","is-referenced-by-count":24,"title":["Does Bicarbonate Transfer Have Relevant Hemodynamic Consequences in Standard Hemodialysis?"],"prefix":"10.1159","volume":"23","author":[{"given":"Luca","family":"Gabutti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Ross","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Duchini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio","family":"Mombelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Marone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2005,8,25]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1038%2Fki.1986.242"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1159%2F000180501"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1159%2F000045923"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1172%2FJCI112924"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1159%2F000185265"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2FS0272-6386%2897%2990292-4"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM198401053100105"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.126.6.1445"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1159%2F000169600"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1093%2Fndt%2Fgfg383"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.3109%2F00365517109080201"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.138.4.927"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00134-002-1443-y"}],"container-title":["Blood Purification"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/87193","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/87193","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:19:56Z","timestamp":1745464796000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000087193"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005]]},"references-count":13,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2005,8,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000087193","archive":["Portico"],"relation":{},"ISSN":["0253-5068","1421-9735"],"issn-type":[{"value":"0253-5068","type":"print"},{"value":"1421-9735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005]]}}}