{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T14:38:34Z","timestamp":1772894314427,"version":"3.50.1"},"reference-count":10,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Allergy Immunol"],"published-print":{"date-parts":[[2005]]},"abstract":"<i>Background:<\/i> The pathophysiology of infantile asthma may differ from that in older children or in adults, partly because of the different immune response depending upon maturation. In adult mice, the sensitizing dose of antigen is known to be critical to the polarized development of helper T cell subsets and allergic airway inflammation. We wanted to know the characteristics of allergic airway inflammation of infantile asthma by developing a murine model. <i>Methods:<\/i> BALB\/C mice at different stages of maturation (juvenile: 3 days after birth; adult: 8 weeks of age) were sensitized with 10 or 1,000 \u00b5g ovalbumin (OVA) or vehicle. The animals were then challenged with aerosolized OVA or saline once a day during 6 consecutive days. After the final challenge, bronchial hyperresponsiveness (BHR), bronchoalveolar lavage fluid (BALF), histological changes in the airways and immunological status were examined. <i>Results:<\/i> In both juvenile and adult animals, sensitization with 10 \u00b5g OVA induced the T helper 2 response (elevated IL-4 and decreased IFN-\u03b3 levels). BHR, airway eosinophilia, the inflammatory cell infiltration, goblet cell metaplasia (GCM), and IgE antibody production were more prominent in animals given this dose than 1,000 \u00b5g OVA. Among these responses, GCM as well as BALF IL-4, and BHR were comparable between juvenile and adult animals, whereas other parameters were lower in juvenile animals, especially in those given 1,000 \u00b5g OVA. <i>Conclusion:<\/i> GCM and, consequently, airway mucus hypersecretion may be an important component of allergic airway inflammation in infantile asthma.<\/jats:p>","DOI":"10.1159\/000087357","type":"journal-article","created":{"date-parts":[[2005,8,10]],"date-time":"2005-08-10T14:11:38Z","timestamp":1123683098000},"page":"51-58","source":"Crossref","is-referenced-by-count":17,"title":["Characteristic Features of Allergic Airway Inflammation in a Murine Model of Infantile Asthma"],"prefix":"10.1159","volume":"138","author":[{"given":"Yasushi","family":"Ohki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenichi","family":"Tokuyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroo","family":"Mayuzumi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Sato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harumi","family":"Koyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takumi","family":"Takizawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirokazu","family":"Arakawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Mochizuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihiro","family":"Morikawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2005,9,16]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM200101043440106"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM200101113440206"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2249.1999.01036.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1080%2F009841099157340"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1172%2FJCI115428"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2FS0091-6749%2899%2970456-2"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2F0091-6749%2892%2990133-M"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2898%2905104-6"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1126%2Fscience.271.5256.1728"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1203%2F01.PDR.0000030882.20888.AF"}],"container-title":["International Archives of Allergy and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/87357","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/87357","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:21:40Z","timestamp":1745464900000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000087357"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005]]},"references-count":10,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2005,9,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000087357","archive":["Portico"],"relation":{},"ISSN":["1018-2438","1423-0097"],"issn-type":[{"value":"1018-2438","type":"print"},{"value":"1423-0097","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005]]}}}