{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T14:51:59Z","timestamp":1761058319207,"version":"3.40.4"},"reference-count":19,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Allergy Immunol"],"published-print":{"date-parts":[[2005]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Interleukin-16 (IL-16) has been characterized as a chemoattractant for a variety of CD4+ T cells. Several inflammatory diseases, including allergic disorders, have been reported to correlate with IL-16. We first examined the IL-16 expression of serum and mucosal tissue in patients with allergic rhinitis. &lt;i&gt;Methods:&lt;\/i&gt; Forty-eight patients with a clinical history of house dust mite (HDM) or pollen-sensitive allergic rhinitis were included in this study. Serum IL-16 was analyzed by enzyme-linked immunosorbent assay (ELISA). IL-16 expression of nasal mucosa was detected by immunohistochemistry. &lt;i&gt;Results:&lt;\/i&gt; IL-16 levels were elevated in the serum of patients with allergic rhinitis compared with normal controls. In particular, serum IL-16 levels in HDM-sensitive patients were higher than those in pollen-sensitive patients. IL-16 was significantly correlated with eosinophils in the peripheral blood of allergic rhinitis patients. Histologically, IL-16 was expressed in infiltrated lymphocytes and nasal gland cells. &lt;i&gt;Conclusions:&lt;\/i&gt; Our data indicate that one of the sources of elevated serum IL-16 in allergic patients may be gland cells and lymphocytes in allergic nasal mucosa. This IL-16 cytokine may be strongly associated with the developmental mechanism of allergic rhinitis.<\/jats:p>","DOI":"10.1159\/000087359","type":"journal-article","created":{"date-parts":[[2005,8,11]],"date-time":"2005-08-11T13:30:46Z","timestamp":1123767046000},"page":"67-72","source":"Crossref","is-referenced-by-count":11,"title":["Expression of Interleukin-16 in Allergic Rhinitis"],"prefix":"10.1159","volume":"138","author":[{"given":"Masayuki","family":"Karaki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroaki","family":"Dobashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryuichi","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michiaki","family":"Tokuda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshihiko","family":"Ishida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nozomu","family":"Mori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2005,9,16]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.91.11.5109"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1034%2Fj.1398-9995.2001.00916.x"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.2500%2F108854101778148683"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2FS0091-6749%2897%2970152-0"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1053%2Fgast.2000.18164"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1067%2Fmai.2002.130049"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1378%2Fchest.123.3_suppl.431S"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2FS0161-5890%2802%2900013-5"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1159%2F000053777"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1159%2F000053835"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1159%2F000053847"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2567.2000.00997.x"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1124%2Fjpet.102.036939"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1165%2Frcmb.2002-0043OC"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1034%2Fj.1398-9995.2002.23687.x"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1067%2Fmai.2002.122234"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1034%2Fj.1398-9995.2001.00916.x"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1378%2Fchest.120.2.595"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1067%2Fmai.2001.112373"}],"container-title":["International Archives of Allergy and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/87359","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/87359","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:21:42Z","timestamp":1745464902000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000087359"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005]]},"references-count":19,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2005,9,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000087359","archive":["Portico"],"relation":{},"ISSN":["1018-2438","1423-0097"],"issn-type":[{"type":"print","value":"1018-2438"},{"type":"electronic","value":"1423-0097"}],"subject":[],"published":{"date-parts":[[2005]]}}}