{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T20:31:33Z","timestamp":1774125093717,"version":"3.50.1"},"reference-count":23,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dement Geriatr Cogn Disord"],"published-print":{"date-parts":[[2005]]},"abstract":"<jats:p>The existence of an association between apolipoprotein E (APOE) and Alzheimer\u2019s disease (AD) has been reported in several studies. The possession of an ApoE \u03b54 allele is now considered a genetic risk factor for sporadic AD. There has been a growing agreement about the role exerted by the ApoE \u03b54 allele on the neuropsychological profile and the rate of cognitive decline in AD patients. However, a more controversial issue remains about a possible influence of the APOE genotype on acetylcholinesterase inhibitor therapy response in AD patients. In order to address this issue, 81 patients diagnosed as having probable AD were evaluated by a complete neuropsychological test battery at the time of diagnosis (baseline) and after 12\u201316 months (retest). Patients were divided into two subgroups: (1) treated with donepezil at a dose of 5 mg once a day (n = 41) and (2) untreated (n = 40). Donepezil therapy was started after baseline evaluation. The APOE genotype was determined according to standardized procedures. We evaluated the possible effect of the APOE genotype on the neuropsychological tasks in relation to donepezil therapy. The statistical analysis of the results showed a global worsening of cognitive performances for all AD patients at the retest. Differences in the clinical outcome were analysed in the four subgroups of AD patients for each neuropsychological task. ApoE \u03b54 carriers\/treated patients had improved or unchanged scores at retest evaluation for the following tasks: visual and verbal memory, visual attention and inductive reasoning and Mini Mental State Examination. These results indicate an effect of donepezil on specific cognitive domains (attention and memory) in the ApoE \u03b54 carriers with AD. This might suggest an early identification of AD patients carrying at least one \u03b54 allele as responders to donepezil therapy.<\/jats:p>","DOI":"10.1159\/000087371","type":"journal-article","created":{"date-parts":[[2005,8,10]],"date-time":"2005-08-10T14:11:38Z","timestamp":1123683098000},"page":"254-261","source":"Crossref","is-referenced-by-count":70,"title":["Apolipoprotein E \u03b54 Allele Differentiates the Clinical Response to Donepezil in Alzheimer\u2019s Disease"],"prefix":"10.1159","volume":"20","author":[{"given":"A.","family":"Bizzarro","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Marra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Acciarri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Valenza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.D.","family":"Tiziano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Brahe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Masullo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2005,9,12]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1001%2Farchneur.55.7.964"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1159%2F000017034"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.90.20.9649"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1159%2F000017130"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1001%2Farchneur.59.7.1154"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1159%2F000079191"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2FS0197-4580%2801%2900223-8"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291099-1166%28199809%2913%3A9%3C625%3A%3AAID-GPS835%3E3.0.CO%3B2-2"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1159%2F000051238"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1159%2F000051232"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1159%2F000079201"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.tpj.6500267"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1468-1331.2003.00757.x"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1007%2Fs007020170066"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2804%2916499-4"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016%2FS0924-977X%2800%2900067-5"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1600-0447.1979.tb00264.x"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016%2F0140-6736%2891%2992823-K"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016%2FS0006-2952%2802%2901514-9"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1126%2Fscience.1411529"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1097%2F00001756-199503000-00012"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016%2FS0169-328X%2898%2900236-8"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1001%2Farchneur.58.3.442"}],"container-title":["Dementia and Geriatric Cognitive Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/87371","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/87371","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:21:58Z","timestamp":1745464918000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000087371"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005]]},"references-count":23,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2005,9,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000087371","archive":["Portico"],"relation":{},"ISSN":["1420-8008","1421-9824"],"issn-type":[{"value":"1420-8008","type":"print"},{"value":"1421-9824","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005]]}}}