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Apart from the correlation of about one third of the sSMC cases with a specific clinical picture, i.e. the i(18p), der(22), i(12p) (Pallister Killian syndrome) and inv dup(22) (cat-eye) syndromes, most of the remaining sSMC have not yet been correlated with clinical syndromes. Recently, we reviewed the available &gt;1600 sSMC cases (Liehr T, sSMC homepage: http:\/\/mti-n.mti.uni-jena.de\/\u223chuwww\/MOL_ZYTO\/sSMC.htm). A total of 387 cases (including the 45 new cases reported here) have been molecularly cytogenetically characterized with regard to their chromosomal origin, the presence of euchromatin, heterochromatin and satellite material. Based on analysis of these cases we present the first draft of a basic genotype-phenotype correlation for sSMC for all human chromosomes apart from the chromosomes Y, 10, 11 and 13.\u00a0\u00a0\u00a0<\/jats:p>","DOI":"10.1159\/000087510","type":"journal-article","created":{"date-parts":[[2005,11,4]],"date-time":"2005-11-04T08:38:02Z","timestamp":1131093482000},"page":"23-34","source":"Crossref","is-referenced-by-count":127,"title":["Small supernumerary marker chromosomes \u2013 progress towards a genotype-phenotype 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