{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T13:48:24Z","timestamp":1791726504283,"version":"4.3.4"},"reference-count":16,"publisher":"S. Karger AG","issue":"1-2","license":[{"start":{"date-parts":[[2005,11,3]],"date-time":"2005-11-03T00:00:00Z","timestamp":1130976000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2005,11,3]],"date-time":"2005-11-03T00:00:00Z","timestamp":1130976000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cytogenet Genome Res"],"published-print":{"date-parts":[[2006]]},"abstract":"Chromosome segment 12q13\u2192q15 recombines with many different chromosome bands in lipomas and at least ten recurrent translocations have been identified. The <i>HMGA2<\/i> gene is often rearranged, but little is known about the molecular consequences at other breakpoints. Fusion genes between <i>HMGA2<\/i> (12q14\u2192q15) and <i>LPP<\/i> (3q27\u2192q28), <i>LHFP<\/i> (13q12) and <i>CMKOR1<\/i> (2q37) have been reported. In the present study, eight lipomas with rearrangements involving chromosome bands 12q14\u2192q15 and 5q32\u2192q33 were analyzed. In chromosome 5, five of the cases had a breakpoint in the 5\u2032 part of <i>EBF<\/i> in 5q33, while three cases had breakpoints located about 200 kb 3\u2032 of <i>EBF<\/i>. In chromosome 12, the breakpoints clustered to the region of <i>HMGA2<\/i>. Four cases had breaks within the gene and four had breaks 5\u2032 to <i>HMGA2<\/i> where the gene <i>BC058822<\/i> is located. Two versions of an <i>HMGA2\/EBF<\/i> fusion transcript were detected in one case; one transcript was in frame and the other out of frame. Identical <i>EBF\/BC058822<\/i> fusion transcripts, seen in two cases, one of which also had the <i>HMGA2\/EBF<\/i> transcript, were out of frame and resulted in truncation of <i>EBF<\/i>. Since <i>EBF<\/i> and <i>HMGA2<\/i> have different orientations, the findings must be explained by complex aberrations including multiple breaks. The combined data indicate that the pathogenetically significant event is fusion, truncation or transcriptional activation of <i>HMGA2,<\/i> but it can not be excluded that <i>EBF<\/i>, which has been implicated in adipogenesis, contributes to the tumor development.\u00a0\u00a0\u00a0<\/jats:p>","DOI":"10.1159\/000087514","type":"journal-article","created":{"date-parts":[[2005,11,4]],"date-time":"2005-11-04T08:38:02Z","timestamp":1131093482000},"page":"60-66","source":"Crossref","is-referenced-by-count":31,"title":["Truncation and fusion of <i>HMGA2<\/i> in lipomas with rearrangements of 5q32\u2192q33 and 12q14\u2192q15"],"prefix":"10.1159","volume":"112","author":[{"given":"M.","family":"Nilsson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Mertens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"H\u00f6glund","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Mandahl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Panagopoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2005,11,3]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1128%2FMCB.22.22.8015-8025.2002"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2F0092-8674%2895%2990052-7"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2FS0165-4608%2803%2900037-2"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1093%2Fcarcin%2F22.10.1583"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1023%2FA%3A1013129212367"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2FS0165-4608%2801%2900441-1"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1128%2FMCB.22.24.8389-8397.2002"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1002%2Fgcc.10223"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1002%2Fgcc.2870090309"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1006%2Fgeno.1997.4993"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1006%2Fbbrc.2000.4026"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1002%2Fijc.1415"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1006%2Fgeno.1996.0432"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1006%2Fgeno.1999.5778"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1038%2Fng0895-436"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.febslet.2004.08.013"}],"container-title":["Cytogenetic and Genome Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/87514","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/87514","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:22:43Z","timestamp":1745464963000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000087514"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,11,3]]},"references-count":16,"journal-issue":{"issue":"1-2","published-online":{"date-parts":[[2005,11,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000087514","archive":["Portico"],"relation":{},"ISSN":["1424-8581","1424-859X"],"issn-type":[{"value":"1424-8581","type":"print"},{"value":"1424-859X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,11,3]]}}}