{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:26:26Z","timestamp":1791937586419,"version":"4.3.4"},"reference-count":0,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"published-print":{"date-parts":[[2005]]},"abstract":"<jats:p>&lt;i&gt;Aim:&lt;\/i&gt; To assess the predictive value of early MRI and proton MR spectroscopy (&lt;sup&gt;1&lt;\/sup&gt;H-MRS), 11 full-term neonates with severe perinatal asphyxia were studied within 48 h after birth. &lt;i&gt;Methods:&lt;\/i&gt; T&lt;sub&gt;1&lt;\/sub&gt;- and T&lt;sub&gt;2&lt;\/sub&gt;-weighted MRI, diffusion-weighted MRI (DW-MRI), apparent diffusion coefficient of water (ADC) of the basal ganglia and parietal white matter, as well as &lt;sup&gt;1&lt;\/sup&gt;H-MRS of the basal ganglia were performed in a 1.5-Tesla magnetic field. Neurodevelopment was assessed in the survivors for at least 24 months. &lt;i&gt;Results:&lt;\/i&gt; Nine of the 11 neonates had a poor outcome (7 died, 2 developed cerebral palsy). All examinations were normal in the 2 neonates with a good outcome. T&lt;sub&gt;1&lt;\/sub&gt;- and T&lt;sub&gt;2&lt;\/sub&gt;-weighted MRI were abnormal in 7, DWI was abnormal in 7, ADC was abnormal in 5, and elevated lactate\/N-acetylaspartate ratios using &lt;sup&gt;1&lt;\/sup&gt;H-MRS were seen in 7 of the 9 neonates with a poor outcome. None of these 9 had completely normal MRI or &lt;sup&gt;1&lt;\/sup&gt;H-MRS findings. &lt;i&gt;Conclusions:&lt;\/i&gt; Using a combination of T&lt;sub&gt;1&lt;\/sub&gt;- and T&lt;sub&gt;2&lt;\/sub&gt;-weighted MRI, DW-MRI, ADC measurements and &lt;sup&gt;1&lt;\/sup&gt;H-MRS within 48 h after severe perinatal asphyxia, no abnormalities were seen with any of these techniques in both neonates with a good outcome.<\/jats:p>","DOI":"10.1159\/000087628","type":"journal-article","created":{"date-parts":[[2005,8,19]],"date-time":"2005-08-19T13:59:12Z","timestamp":1124459952000},"page":"306-312","source":"Crossref","is-referenced-by-count":59,"title":["Early Diffusion-Weighted MRI and &lt;sup&gt;1&lt;\/sup&gt;H-Magnetic Resonance Spectroscopy in Asphyxiated Full-Term Neonates"],"prefix":"10.1159","volume":"88","author":[{"given":"Carianne","family":"L\u2019Abee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda S.","family":"de Vries","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeroen","family":"van der Grond","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Floris","family":"Groenendaal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2005,11,15]]},"container-title":["Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/87628","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/87628","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:23:31Z","timestamp":1745465011000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000087628"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005]]},"references-count":0,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2005,11,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000087628","archive":["Portico"],"relation":{},"ISSN":["1661-7800","1661-7819"],"issn-type":[{"value":"1661-7800","type":"print"},{"value":"1661-7819","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005]]}}}