{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T04:09:48Z","timestamp":1745554188339,"version":"3.40.4"},"reference-count":15,"publisher":"S. Karger AG","issue":"2-3","license":[{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Digestion"],"published-print":{"date-parts":[[2005]]},"abstract":"<i>Aims:<\/i> To compare safety and efficacy of on-demand pantoprazole 20 mg\/40 mg versus placebo in the long-term management of patients with mild gastroesophageal reflux disease (GERD) after heartburn relief. <i>Methods:<\/i> A total of 634 patients with endoscopically confirmed GERD grade 0\/I and heartburn were included. During the acute phase, patients were treated with pantoprazole 20 mg once daily for 4 weeks. Those patients relieved from heartburn entered the long-term phase, and were randomly assigned to either treatment group pantoprazole 20 mg, 40 mg or placebo. Over 6 months, patients took study medication on demand (antacids as rescue medication) and discontinued the drug once symptoms abated. <i>Results:<\/i> After 4 weeks a total of 87.1%\/90.0% of patients were free of heartburn (ITT\/PP), and entered the subsequent long-term phase. The perceived average daily symptom load (placebo: 3.93, pantoprazole 20 mg: 2.91, pantoprazole 40 mg: 2.71, ITT) and the number of antacid tablets taken (average number, placebo: 0.68, pantoprazole 20 mg: 0.45, pantoprazole 40 mg: 0.33, ITT) were significantly higher in the placebo than in both pantoprazole groups (p < 0.0001), with no statistically significant difference between the two pantoprazole groups. The discontinuation rate due to insufficient control of heartburn was significantly lower in both pantoprazole groups compared to placebo (placebo: 10.9, pantoprazole 20 mg: 2.8, pantoprazole 40 mg: 0.9, ITT). <i>Conclusions:<\/i> Our findings favor on-demand treatment with pantoprazole 20 mg for the long-term management of heartburn in patients with uncomplicated GERD (grade 0\/I) with superiority to placebo.<\/jats:p>","DOI":"10.1159\/000087661","type":"journal-article","created":{"date-parts":[[2005,8,19]],"date-time":"2005-08-19T13:59:12Z","timestamp":1124459952000},"page":"76-85","source":"Crossref","is-referenced-by-count":25,"title":["On-Demand Therapy with Pantoprazole 20 mg as Effective Long-Term Management of Reflux Disease in Patients with Mild GERD: The ORION Trial"],"prefix":"10.1159","volume":"72","author":[{"given":"T.","family":"Scholten","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.P.M.","family":"Dekkers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Sch\u00fctze","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"K\u00f6rner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Bohuschke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Gatz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2005,10,10]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1159%2F000075308"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1097%2F00000441-200311000-00002"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1440-1746.2004.03419.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1136%2Fgut.44.2008.S1"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.3109%2F00365529708996509"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2036.1999.00564.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2036.2001.00943.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1097%2F00042737-200208000-00008"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1080%2F00365520212499"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2036.2004.01999.x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1590%2FS0004-28032002000200010"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1097%2F00042737-200012020-00011"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2036.1998.00381.x"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016%2FS0002-9270%2803%2900014-5"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.2165%2F00019053-200220090-00001"}],"container-title":["Digestion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/87661","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/87661","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:23:40Z","timestamp":1745465020000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000087661"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005]]},"references-count":15,"journal-issue":{"issue":"2-3","published-online":{"date-parts":[[2005,10,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000087661","archive":["Portico"],"relation":{},"ISSN":["0012-2823","1421-9867"],"issn-type":[{"type":"print","value":"0012-2823"},{"type":"electronic","value":"1421-9867"}],"subject":[],"published":{"date-parts":[[2005]]}}}