{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:51:27Z","timestamp":1787017887895,"version":"build-2736575974"},"reference-count":6,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Res Paediatr"],"published-print":{"date-parts":[[2005]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Frontoethmoidal encephalomeningocele (FEEM) is a congenital neural tube defect which is more common in Southeast Asia. Its etiology is unknown. No one has ever reported endocrine abnormalities in this condition. &lt;i&gt;Method:&lt;\/i&gt; We retrospectively reviewed medical records of 84 patients with FEEM, primarily focused on the clinical data suggestive of endocrine disorders including growth parameter, thyroid function test, serum electrolyte and serum osmolality. &lt;i&gt;Results:&lt;\/i&gt; Nasoethmoidal was the most common subtype found in this study. Sixty-four percent of our patients had their heights below the mean height of normal Thai children. The incidence of hypothyroidism (1:28), central DI (1:42) and GHD (1:42) were higher than that in the general population. &lt;i&gt;Conclusion:&lt;\/i&gt; A significant number of patients with FEEM had clinical evidences suggestive of hypothalamopituitary insufficiency. Appropriate replacement therapy is mandatory in order to prevent untoward complications.<\/jats:p>","DOI":"10.1159\/000087691","type":"journal-article","created":{"date-parts":[[2005,8,19]],"date-time":"2005-08-19T09:59:12Z","timestamp":1124445552000},"page":"64-67","source":"Crossref","is-referenced-by-count":4,"title":["Endocrine Abnormalities in Patients with Frontoethmoidal Encephalomeningocele"],"prefix":"10.1159","volume":"64","author":[{"given":"S.","family":"Wacharasindhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"U.","family":"Asawutmangkul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Srivuthana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2005,10,13]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1007%2FBF00296297"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.3171%2Fjns.1972.36.2.0201"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1136%2Fadc.67.6.717"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1159%2F000121262"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1442-200x.2004.01927.x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1136%2Fjech.38.2.89"}],"container-title":["Hormone Research in Paediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/87691","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/87691","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T23:23:50Z","timestamp":1745450630000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000087691"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005]]},"references-count":6,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2005,10,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000087691","archive":["Portico"],"relation":{},"ISSN":["1663-2818","1663-2826"],"issn-type":[{"value":"1663-2818","type":"print"},{"value":"1663-2826","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005]]}}}