{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T12:57:41Z","timestamp":1761742661361,"version":"3.40.4"},"reference-count":9,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Urol Int"],"published-print":{"date-parts":[[2005]]},"abstract":"<i>Purpose:<\/i> Serum prostate-specific antigen (PSA) has a restricted predictive value for prostate cancer in the low-intermediate PSA range (2.5\u201310 ng\/ml). Our aim was to determine the predictive value of the International Prostate Symptom Score (IPSS) for positive prostate needle biopsy (PNB) in patients who underwent transrectal ultrasound (TRUS)-guided prostate biopsy with a low-intermediate PSA level. <i>Patients and Methods:<\/i> Between 2001 and 2004, the data of 389 consecutive patients applying for any urologic complaint to our department and who underwent TRUS-guided prostate biopsy due to an elevated serum PSA and\/or abnormal digital rectal examination (DRE) were retrospectively analyzed. A total of 158 eligible patients with a low-intermediate PSA level were included in the study. The patient\u2019s age, PSA, free PSA, free\/total PSA, prostate volume, PSA density (PSAD), pre-biopsy IPSS were compared in the positive and negative biopsy groups. <i>Results:<\/i> Fifty-eight of 158 patients (37%) who underwent TRUS-guided prostate biopsy had positive PNBs. Forty-eight patients (30%) had abnormal DREs. In the positive PNB group, the mean age was older and PSAD was higher, but the means of the prostate volumes and total IPSS were lower (p < 0.05). Multivariate analysis demonstrated that age and IPSS were independent predictors of a positive PNB (p < 0.05). The odds ratio of mild IPSS for positive PNB controlled for age was 3.0 (95% CI 1.5\u20136.7). Receiver-operating characteristics analysis revealed a mild IPSS (AUC = 0.640) and was a considerable predictor for positive PNB as well as PSAD (AUC = 0.648). The sensitivity and specificity of IPSS with a cutoff value of 7.5 points were 31 and 87% for prediction of prostate cancer detection. <i>Conclusion:<\/i> In the low-intermediate PSA range, mild IPSS may be a predictive factor for positive PNB with a similar specificity of PSAD.<\/jats:p>","DOI":"10.1159\/000087798","type":"journal-article","created":{"date-parts":[[2005,10,10]],"date-time":"2005-10-10T13:31:15Z","timestamp":1128951075000},"page":"222-226","source":"Crossref","is-referenced-by-count":3,"title":["Predictive Value of the International Prostate Symptom Score for Positive Prostate Needle Biopsy in the Low-Intermediate Prostate-Specific Antigen Range"],"prefix":"10.1159","volume":"75","author":[{"given":"Aykut","family":"Kefi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bora","family":"Irer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ismail","family":"Ozdemir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Burcin","family":"Tuna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yigit","family":"Goktay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kutsal","family":"Yoruko\u011flu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adil","family":"Esen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2005,10,5]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1442-2042.2004.00843.x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1001%2Fjama.270.7.860"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1097%2F00005392-199806000-00070"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.urology.2003.08.019"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1097%2F00005392-200001000-00036"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2FS1078-1439%2801%2900155-7"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1097%2F00000478-198812000-00001"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1097%2F01.ju.0000074707.49775.46"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1097%2F00005392-199804000-00047"}],"container-title":["Urologia Internationalis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/87798","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/87798","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:24:58Z","timestamp":1745465098000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000087798"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005]]},"references-count":9,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2005,10,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000087798","archive":["Portico"],"relation":{},"ISSN":["0042-1138","1423-0399"],"issn-type":[{"type":"print","value":"0042-1138"},{"type":"electronic","value":"1423-0399"}],"subject":[],"published":{"date-parts":[[2005]]}}}