{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T03:22:14Z","timestamp":1773285734496,"version":"3.50.1"},"reference-count":12,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ophthalmic Res"],"published-print":{"date-parts":[[2005]]},"abstract":"<i>Purpose:<\/i> The aim of this study was to investigate the antimicrobial and anti-inflammatory properties of an ethanolic extract of propolis, a natural resin produced by honeybees, and to determine synergistic activity between ciprofloxacin and propolis in the treatment of experimental <i>Staphylococcus aureus<\/i> keratitis. <i>Methods:<\/i> Sixteen young New Zealand white rabbits were given intrastromal injections of <i>S. aureus<\/i> strains. Twenty-four hours later, the rabbits were randomly divided into 4 groups: group 1 was treated with topical 0.3% ciprofloxacin drops along with the ethanolic extract of propolis drops; group 2 received topical 0.3% ciprofloxacin drops; group 3 was administered the ethanolic extract of propolis drops, and group 4, the control group, was treated with phosphate-buffered saline (PBS) drops. Drugs were instilled 8 times\/day for 72 h. Twenty-four and 96 h after inoculation of bacteria, the eyes were examined by slit lamp to assess corneal opacity. Corneas were removed to count bacteria. <i>Results:<\/i> Slit lamp examination showed that the corneal opacity scores were significantly lower in eyes that received propolis plus ciprofloxacin than in those treated with ciprofloxacin (p = 0.041) or propolis (p = 0.006) or control eyes treated with PBS (p = 0.0001). There was no significant difference in eyes treated with ciprofloxacin and propolis (p = 1.00). There were significantly fewer bacteria in eyes that received propolis plus ciprofloxacin than in those treated with ciprofloxacin (p = 0.0001) or propolis (p = 0.0001) or control eyes treated with PBS (p = 0.0001). There was no significant difference in eyes treated with ciprofloxacin and propolis (p = 0.38). <i>Conclusions:<\/i> Taking these findings into consideration, we suggest that the ethanolic extract of propolis has antimicrobial and anti-inflammatory properties for <i>S. aureus<\/i> keratitis. The combination of ciprofloxacin and propolis had better therapeutic effects than either agent alone.<\/jats:p>","DOI":"10.1159\/000087943","type":"journal-article","created":{"date-parts":[[2005,9,1]],"date-time":"2005-09-01T07:46:17Z","timestamp":1125560777000},"page":"328-334","source":"Crossref","is-referenced-by-count":28,"title":["Effect of Propolis in the Treatment of Experimental <i>Staphylococcus aureus<\/i> Keratitis in Rabbits"],"prefix":"10.1159","volume":"37","author":[{"given":"H.","family":"Oksuz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Duran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Tamer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Cetin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Silici","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2005,10,21]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2FS0161-6420%2800%2900179-2"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1146%2Fannurev.micro.56.012302.160806"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2F0378-8741%2891%2990135-Z"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2FS0952-3278%2896%2990129-5"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2F0014-5793%2893%2980184-V"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2F0378-8741%2894%2990052-3"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1007%2FBF01941717"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1051%2Fapido%3A19950202"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1136%2Fbjo.85.7.842"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.3109%2F02713689008999556"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1097%2F00003226-199811000-00009"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2FS0278-6915%2897%2900145-2"}],"container-title":["Ophthalmic Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/87943","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/87943","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:26:53Z","timestamp":1745465213000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000087943"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005]]},"references-count":12,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2005,12,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000087943","archive":["Portico"],"relation":{},"ISSN":["0030-3747","1423-0259"],"issn-type":[{"value":"0030-3747","type":"print"},{"value":"1423-0259","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005]]}}}