{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T04:10:00Z","timestamp":1745554200295,"version":"3.40.4"},"reference-count":15,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Fetal Diagn Ther"],"published-print":{"date-parts":[[2005]]},"abstract":"<jats:p>&lt;i&gt;Objective:&lt;\/i&gt; To study whether genetic variability in the gene encoding endothelial nitric oxide synthase (eNOS) affects individual susceptibility to the development of placental abruption during pregnancy. &lt;i&gt;Methods:&lt;\/i&gt; One hundred and sixteen pregnant women with placental abruption and 113 healthy controls were genotyped for Glu298Asp polymorphism in the eNOS gene. Chi-square analysis was used to assess the differences in genotype and allele frequencies between the two groups. &lt;i&gt;Results:&lt;\/i&gt; A statistically similar allelic distribution of eNOS Glu298Asp polymorphism was observed in the two groups, with the frequency of the variant G allele being 66.8% in the abruption group and 68.1% in the control group (OR 0.94, 95% CI: 0.64\u20131.39; p = 0.76). The genotype distribution of the eNOS polymorphism was also found to be statistically similar (p = 0.72). &lt;i&gt;Conclusions:&lt;\/i&gt; The observed genotype data in subjects from eastern Finland suggest that the Glu298Asp polymorphism of the eNOS gene does not contribute to placental abruption in this population.<\/jats:p>","DOI":"10.1159\/000088040","type":"journal-article","created":{"date-parts":[[2005,10,19]],"date-time":"2005-10-19T10:43:33Z","timestamp":1129718613000},"page":"508-511","source":"Crossref","is-referenced-by-count":3,"title":["Endothelial Nitric Oxide Synthase Polymorphism Is Not Associated with Placental Abruption in Finnish Women"],"prefix":"10.1159","volume":"20","author":[{"given":"Sari","family":"Toivonen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leea","family":"Keski-Nisula","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eeva-Liisa","family":"Romppanen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seppo","family":"Helisalmi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kari","family":"Punnonen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seppo","family":"Heinonen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2005,10,20]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1038%2F288373a0"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2F0014-5793%2893%2981706-6"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2F0002-9378%2895%2990500-6"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.2741%2Ftseng"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.85.6.2318"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1067%2Fmob.2001.115048"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1161%2Fhy1201.097305"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1007%2Fs004390000454"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007%2Fs11906-003-0006-0"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2FS0020-7292%2896%2902789-0"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1097%2F00006254-200205000-00022"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1055%2Fs-2002-36868"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2FS1521-6934%2803%2900006-3"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016%2FS0301-2115%2800%2900492-9"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016%2FS0301-2115%2801%2900496-1"}],"container-title":["Fetal Diagnosis and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/88040","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/88040","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:27:44Z","timestamp":1745465264000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000088040"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005]]},"references-count":15,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2005,12,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000088040","archive":["Portico"],"relation":{},"ISSN":["1015-3837","1421-9964"],"issn-type":[{"type":"print","value":"1015-3837"},{"type":"electronic","value":"1421-9964"}],"subject":[],"published":{"date-parts":[[2005]]}}}