{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T06:57:48Z","timestamp":1782543468109,"version":"3.54.5"},"reference-count":9,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiology"],"published-print":{"date-parts":[[2005]]},"abstract":"<jats:p>The study population consisted of 16 patients with rheumatic mitral stenosis undergoing percutaneous transluminal mitral valvuloplasty (group 1). The plasma levels of tumor necrosis factor-\u03b1 (TNF-\u03b1) and interleukin-10 (IL-10) in the femoral vein and the right and left atria before valvuloplasty were determined by ELISA. Additionally, we measured plasma concentrations of TNF-\u03b1 and IL-10 in the venous blood obtained from 19 control patients, including 12 healthy volunteers in sinus rhythm (group 2) and 7 patients in permanent lone atrial fibrillation (group 3). The venous plasma levels of TNF-\u03b1 were significantly elevated in group 1 patients compared with group 2 patients (p &lt; 0.002). Correlation analysis demonstrated that there was a significantly direct relationship between the plasma TNF-\u03b1 and IL-10 concentrations in the left atrial, right atrial and peripheral venous blood (p &lt; 0.008, r = 0.640; p &lt; 0.04, r = 0.538; p&lt; 0.03, r = 0.571, respectively). In conclusion, the plasma concentrations of TNF-\u03b1 of patients with rheumatic mitral stenosis were significantly higher than those of healthy volunteers. In addition, there was a significantly direct relationship between the soluble TNF-\u03b1 and IL-10 concentrations in the atrial and peripheral venous blood, indicating a balance between circulating TNF-\u03b1 and IL-10 levels in patients with rheumatic mitral stenosis.<\/jats:p>","DOI":"10.1159\/000088104","type":"journal-article","created":{"date-parts":[[2005,9,7]],"date-time":"2005-09-07T07:45:22Z","timestamp":1126079122000},"page":"171-175","source":"Crossref","is-referenced-by-count":13,"title":["Balance between Plasma Levels of Tumor Necrosis Factor-\u03b1 and Interleukin-10 in Rheumatic Mitral Stenosis"],"prefix":"10.1159","volume":"104","author":[{"given":"Mien-Cheng","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsueh-Wen","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiung-Jen","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-Hsu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teng-Hung","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chien-Jen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Chin","family":"Hung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2005,10,4]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1006%2Fclin.1995.1140"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1172%2FJCI115939"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2FS0002-9149%2803%2900131-0"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2FS0735-1097%2800%2900721-X"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2362.2002.01069.x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1093%2Frheumatology%2F38.4.293"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2F0002-9149%2892%2991000-T"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1159%2F000177141"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1006%2Fbbrc.1999.0353"}],"container-title":["Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/88104","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/88104","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:28:07Z","timestamp":1745465287000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000088104"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005]]},"references-count":9,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2005,9,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000088104","archive":["Portico"],"relation":{},"ISSN":["0008-6312","1421-9751"],"issn-type":[{"value":"0008-6312","type":"print"},{"value":"1421-9751","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005]]}}}