{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T18:05:11Z","timestamp":1758823511750,"version":"3.40.4"},"reference-count":15,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med Princ Pract"],"published-print":{"date-parts":[[2005]]},"abstract":"<i>Objectives:<\/i> To determine the frequency of isolation and antibiotic-susceptibility patterns of clinically significant bacterial pathogens isolated from blood. <i>Materials and Methods:<\/i> The study was conducted over a period of 8 years (1995\u20132002) at Infectious Diseases Hospital (IDH), Kuwait. Demographic and clinical data were obtained from medical records. 18,535 blood cultures were analyzed. Disk diffusion method was used to perform antibiotic-susceptibility testing. Minimum inhibitory concentrations of 9 antimicrobials were determined using E-test. Double disk (potentiation) test and E-test ESBL strips were used to detect the production of extended-spectrum beta-lactamases (ESBLs). <i>Results:<\/i><i>Salmonella <\/i>spp. and <i>Brucella<\/i> spp. were predominant blood isolates, and represented 60.6 and 30.0% of all clinically significant episodes of bloodstream infections, respectively. Among the <i>Salmonella, Salmonella enterica<\/i> serotypes <i>typhi <\/i>and <i>paratyphi A <\/i>were most frequently isolated. The percentage of multidrug resistance (MDR) among them varied from 22 to 51%. A high percentage (40%) of MDR <i>S. enterica<\/i> serotypes <i>typhi<\/i> and <i>paratyphi A<\/i> also showed reduced susceptibility to ceftriaxone and ciprofloxacin. <i>Conclusion:<\/i> During the study period, <i>Salmonella <\/i>spp. and <i>Brucella<\/i> spp. were predominant blood isolates. MDR <i>S. enterica<\/i> serotypes <i>typhi <\/i>and <i>paratyphi A<\/i>, with reduced susceptibility to ceftriaxone and ciprofloxacin, are among the most frequent causes of bloodstream infections in IDH, suggesting the need to monitor their susceptibility.<\/jats:p>","DOI":"10.1159\/000088115","type":"journal-article","created":{"date-parts":[[2005,10,14]],"date-time":"2005-10-14T08:09:01Z","timestamp":1129277341000},"page":"417-421","source":"Crossref","is-referenced-by-count":13,"title":["Incidence of Bloodstream Infections in a Speciality Hospital in Kuwait: 8-Year Experience"],"prefix":"10.1159","volume":"14","author":[{"given":"T.S.","family":"Dimitrov","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Panigrahi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Emara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Al-Nakkas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Awni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Passadilla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2008,7,9]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1007%2FBF02185852"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1136%2Fjcp.41.6.668"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1093%2Fjac%2Fdkg201"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1136%2Fbmj.320.7229.213"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-3156.1996.d01-80.x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1159%2F000072293"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1159%2F000078319"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1007%2Fs100960050453"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1001%2Farchinte.154.8.841"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1086%2F313710"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2FS0924-8579%2899%2900131-4"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2F0002-9343%2891%2990349-3"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2895%2991254-1"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.3201%2Feid0604.000420"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016%2FS0196-4399%2803%2980027-2"}],"container-title":["Medical Principles and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/88115","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/88115","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:28:23Z","timestamp":1745465303000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000088115"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005]]},"references-count":15,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2005,12,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000088115","archive":["Portico"],"relation":{},"ISSN":["1011-7571","1423-0151"],"issn-type":[{"type":"print","value":"1011-7571"},{"type":"electronic","value":"1423-0151"}],"subject":[],"published":{"date-parts":[[2005]]}}}