{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T04:10:10Z","timestamp":1745554210979,"version":"3.40.4"},"reference-count":19,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respiration"],"published-print":{"date-parts":[[2006]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Exposure to dust in the cotton industry is associated with respiratory dysfunction. Healthy subjects challenged with cotton bract extract (CBE) develop transient airway hyperresponsiveness. CBE, a major component of cotton dust, is potentially an important agent for studying byssinosis. &lt;i&gt;Objectives:&lt;\/i&gt; To compare airway responses to cotton dust extract (CDE) and CBE in healthy subjects. &lt;i&gt;Methods:&lt;\/i&gt; In 21 healthy, non-smoking subjects we compared the effects of CBE and CDE in a double-blind random order, following a 10-min aerosol inhalation. The response to methacholine (MCh) 2 h following CBE or CDE was measured. Lung function was recorded using maximal (MEFV) and partial expiratory flow volume (PEFV) curves, measuring MEF at 60% of baseline vital capacity below total lung capacity [MEF&lt;sub&gt;40%&lt;\/sub&gt;(P)] on the PEFV curve. Responders were subjects who developed a 20% or greater fall in MEF&lt;sub&gt;40%&lt;\/sub&gt;(P) following extract challenge. Endotoxin levels were low for CBE (5.71 EU\/mg) and CDE (31.88 EU\/mg). &lt;i&gt;Results:&lt;\/i&gt; There were 18 responders to CBE and 17 responders to CDE.The average maximal falls in MEF&lt;sub&gt;40%&lt;\/sub&gt;(P) were 70 \u00b1 4.9 and 70 \u00b1 4.4% of baseline (nonsignificant) following CBE and CDE, respectively. All subjects enhanced their MCh response following CBE or CDE. The MCh dose which reduced MEF&lt;sub&gt;40%&lt;\/sub&gt;(P) by 40% was identical for CBE and CDE (1.3 \u00b5g\/ml). &lt;i&gt;Conclusions:&lt;\/i&gt; We conclude that CBE and CDE exert similar physiologic effects.<\/jats:p>","DOI":"10.1159\/000088354","type":"journal-article","created":{"date-parts":[[2005,9,26]],"date-time":"2005-09-26T09:01:09Z","timestamp":1127725269000},"page":"41-47","source":"Crossref","is-referenced-by-count":5,"title":["Airway Responses to the Inhalation of Cotton Dust and Cotton Bract Extracts"],"prefix":"10.1159","volume":"73","author":[{"given":"E.Neil","family":"Schachter","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eugenija","family":"Zuskin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marion","family":"Buck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theodore J.","family":"Witek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Godbold","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noah","family":"Roy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent","family":"Castranova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Whitmer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul D.","family":"Siegel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabeth C.","family":"Bluhm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2006,2,10]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1136%2Fthx.51.6.632"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1136%2Fthx.52.1.22"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1007%2FBF02160619"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2F0034-5687%2878%2990063-4"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007%2FBF02713699"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1378%2Fchest.79.4.43S"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1159%2F000049370"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1172%2FJCI106073"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2F0091-6749%2873%2990141-3"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1080%2F15287399409531879"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.2307%2F2529321"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2F0091-6749%2885%2990731-6"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1378%2Fchest.104.3.825"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1136%2Foem.60.12.935"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1002%2Fajim.4700220204"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM198709033171005"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1172%2FJCI112750"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1378%2Fchest.110.1.263"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1002%2Fajim.4700120605"}],"container-title":["Respiration"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/88354","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/88354","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:30:24Z","timestamp":1745465424000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000088354"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006]]},"references-count":19,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2006,2,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000088354","archive":["Portico"],"relation":{},"ISSN":["0025-7931","1423-0356"],"issn-type":[{"type":"print","value":"0025-7931"},{"type":"electronic","value":"1423-0356"}],"subject":[],"published":{"date-parts":[[2006]]}}}