{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T06:41:05Z","timestamp":1759992065860,"version":"3.40.4"},"reference-count":8,"publisher":"S. Karger AG","issue":"2-3","license":[{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Digestion"],"published-print":{"date-parts":[[2005]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Relapse after an initial response to infliximab therapy poses a problem for maintenance treatment. &lt;i&gt;Aim:&lt;\/i&gt; To assess the effects of increasing the infliximab dosage in Crohn\u2019s disease (CD) patients who initially responded but flared during maintenance therapy. &lt;i&gt;Methods:&lt;\/i&gt; This was an observational study. Twelve CD patients with both inflammatory and fistulizing manifestations were included. All patients initially responded to 5 mg\/kg of infliximab, relapsed during maintenance therapy, and were treated with 10 mg\/kg. The Harvey-Bradshaw index, the fistula activity, and steroid use were assessed before and after treatment with the increased dose of infliximab. &lt;i&gt;Results:&lt;\/i&gt; The mean Harvey-Bradshaw index score after flare-up during treatment with 5 mg\/kg of infliximab was 13.5 \u00b1 3.7. Treatment with 10 mg\/kg, in a mean of 3.3 infusions, decreased the activity score to a mean of 8.8 \u00b1 2.5. Two patients were weaned off prednisone, and a reduced dose was possible in the other steroid-treated patients. &lt;i&gt;Conclusions:&lt;\/i&gt; Increasing the infliximab dose may be beneficial in CD patients who initially responded to therapy, but relapsed during maintenance with the lower dosage.<\/jats:p>","DOI":"10.1159\/000088367","type":"journal-article","created":{"date-parts":[[2005,9,19]],"date-time":"2005-09-19T09:26:42Z","timestamp":1127122002000},"page":"124-128","source":"Crossref","is-referenced-by-count":10,"title":["Increasing the Infliximab Dose Is Beneficial in Crohn\u2019s Disease Patients Who Responded to a Lower Dose and Relapsed"],"prefix":"10.1159","volume":"72","author":[{"given":"Yoram","family":"Menachem","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin","family":"Avidan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Lavy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alon","family":"Lang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eytan","family":"Bardan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Herma","family":"Fidder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon","family":"Bar-Meir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yehuda","family":"Chowers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2005,10,10]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMra020831"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM199710093371502"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2802%2908512-4"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMoa020888"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2FS0016-5085%2899%2970332-X"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2880%2992767-1"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1053%2Fj.gastro.2003.11.014"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2FS0002-9270%2802%2905829-X"}],"container-title":["Digestion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/88367","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/88367","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:30:29Z","timestamp":1745465429000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000088367"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005]]},"references-count":8,"journal-issue":{"issue":"2-3","published-online":{"date-parts":[[2005,10,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000088367","archive":["Portico"],"relation":{},"ISSN":["0012-2823","1421-9867"],"issn-type":[{"type":"print","value":"0012-2823"},{"type":"electronic","value":"1421-9867"}],"subject":[],"published":{"date-parts":[[2005]]}}}