{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T18:05:53Z","timestamp":1767981953833,"version":"3.49.0"},"reference-count":14,"publisher":"S. Karger AG","issue":"2-3","license":[{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Digestion"],"published-print":{"date-parts":[[2005]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Toxic megacolon (TM) is a potentially lethal complication of idiopathic inflammatory bowel disease or infectious colitis, characterized by total or segmental non-obstructive colonic dilatation of at least 6 cm associated with systemic toxicity. &lt;i&gt;Methods:&lt;\/i&gt; Overall, 15 patients had surgery for TM at our institutions over a 10-year period (1993\u20132003). In contrast to other studies that used medical therapy as the first-line treatment for TM, in our experience all patients underwent surgery as soon as possible after diagnosis of TM (early surgery). &lt;i&gt;Results:&lt;\/i&gt; 14 patients underwent subtotal colectomy with terminal ileostomy, while for 1 patient the surgical procedure consisted only in a decompressive cecostomy. Two major complications occurred consisting of 2 cases of multiple organ failure leading to death. No other major complications or deaths were reported. The overall mortality rate was therefore 13% (0% in patients &lt;65 years). &lt;i&gt;Conclusion:&lt;\/i&gt; This study shows that early surgery has the potential to represent a valid therapeutic strategy for patients with TM resulting in a small number of TM-related complications and deaths. Elderly patients seem to have a high risk of multiple organ dysfunction syndrome and post-surgical death.<\/jats:p>","DOI":"10.1159\/000088369","type":"journal-article","created":{"date-parts":[[2005,9,19]],"date-time":"2005-09-19T09:26:42Z","timestamp":1127122002000},"page":"146-149","source":"Crossref","is-referenced-by-count":13,"title":["Early Surgery for the Treatment of Toxic Megacolon"],"prefix":"10.1159","volume":"72","author":[{"given":"Carmelo","family":"D\u2019Amico","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Vitale","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Imerio","family":"Angriman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cesare","family":"Ruffolo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"D\u2019Amico","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Domenico","family":"Valente","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maurizio","family":"Berto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincenzo","family":"Vella","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Scarpa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Davide Francesco","family":"D\u2019Amico","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2005,10,10]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2897%2910475-5"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1001%2Farchsurg.136.12.1396"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1097%2F00000658-200203000-00008"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1572-0241.2002.05691.x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2F0002-9610%2884%2990042-4"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1097%2F00004836-198504000-00007"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1097%2F00000658-197612000-00004"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2FS0002-9610%2888%2980070-9"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1136%2Fbmj.4.5737.703"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2FS0002-9610%2802%2900879-6"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1572-0241.2003.07696.x"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1007%2Fs11938-005-0011-2"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1097%2F00042737-200411000-00014"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1572-0241.2000.02019.x"}],"container-title":["Digestion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/88369","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/88369","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:30:30Z","timestamp":1745465430000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000088369"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005]]},"references-count":14,"journal-issue":{"issue":"2-3","published-online":{"date-parts":[[2005,10,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000088369","archive":["Portico"],"relation":{},"ISSN":["0012-2823","1421-9867"],"issn-type":[{"value":"0012-2823","type":"print"},{"value":"1421-9867","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005]]}}}