{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T00:16:55Z","timestamp":1785457015004,"version":"3.56.0"},"reference-count":12,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"published-print":{"date-parts":[[2005]]},"abstract":"<jats:p>We have previously shown that the peroxidase inhibitor methimazole (1-methyl-2-mercapto imidazole; MMI) is a noncytotoxic inhibitor of melanin production in cultured B16 melanocytes. It was further demonstrated that the topical application of 5% MMI on brown guinea pig skin for 6 weeks causes a significant reduction in the amount of epidermal melanin, resulting in visually recognizable cutaneous depigmentation. Herein, we report a 27-year-old male with postinflammatory hyperpigmentation (due to acid burn), successfully treated with topical MMI as a new skin depigmenting agent. Topical 5% MMI caused a moderate to marked improvement of the hyperpigmented lesions within 6 weeks of once-daily application. Topical MMI was well tolerated by the patient and did not affect the level of serum thyroid hormones (free thyroxin, free triiodothyronine and the thyroid-stimulating hormone). Unlike most known depigmenting agents, such as hydroquinone and kojic acid, MMI is a noncytotoxic, nonmutagenic compound, and it is possible that MMI could serve as a novel agent for the treatment of hyperpigmentary disorders in human.<\/jats:p>","DOI":"10.1159\/000088509","type":"journal-article","created":{"date-parts":[[2005,11,15]],"date-time":"2005-11-15T07:33:49Z","timestamp":1132040029000},"page":"360-362","source":"Crossref","is-referenced-by-count":32,"title":["Topical Methimazole as a New Treatment for Postinflammatory Hyperpigmentation: Report of the First Case"],"prefix":"10.1159","volume":"211","author":[{"given":"Behrooz","family":"Kasraee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farhad","family":"Handjani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amin","family":"Parhizgar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gholamhosein R.","family":"Omrani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Reza","family":"Fallahi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitra","family":"Amini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Nikbakhsh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Tran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ambros","family":"H\u00fcgin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Sorg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Hilaire","family":"Saurat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2005,12,8]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.0022-202X.2004.22509.x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.0022-202x.2001.01621.x"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.3109%2F09546639709160535"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1248%2Fbpb.26.1365"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2FS0006-2952%2898%2900340-2"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1006%2Frtph.2000.1442"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2F0378-4274%2891%2990074-G"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1600-0749.1998.tb00705.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1159%2F000066242"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1159%2F000066439"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291096-9888%28199909%2934%3A9%3C922%3A%3AAID-JMS851%3E3.0.CO%3B2-F"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111%2F1523-1747.ep12470147"}],"container-title":["Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/88509","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/88509","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:31:12Z","timestamp":1745465472000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000088509"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005]]},"references-count":12,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2005,11,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000088509","archive":["Portico"],"relation":{},"ISSN":["1018-8665","1421-9832"],"issn-type":[{"value":"1018-8665","type":"print"},{"value":"1421-9832","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005]]}}}