{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T23:36:08Z","timestamp":1773272168527,"version":"3.50.1"},"reference-count":13,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Nutr Metab"],"published-print":{"date-parts":[[2005]]},"abstract":"<jats:p>This study was designed to investigate the response to a high-cholesterol, n\u20133 polyunsaturated fatty acid (PUFA) or n\u20136 PUFA diet in rats and hamsters. Animals were fed n\u20133 or n\u20136 PUFA with a cholesterol-free diet, or with a diet enriched with cholesterol (0.5%, w\/w) for 2 weeks. In rats and hamsters fed a cholesterol-free diet, plasma cholesterol, triglycerides and very-low-density lipoprotein (VLDL)-triglyceride levels in n\u20133 PUFA group were significantly lower than those in n\u20136 PUFA group. In contrast, when diets were supplemented with 0.5% cholesterol, the plasma cholesterol- and triglyceride-lowering effect of dietary n\u20133 PUFA disappeared. In hamsters fed with the atherogenic diet (0.5% dietary cholesterol) for 2 weeks, n\u20133 PUFA induced hypercholesterolemia more than n\u20136 PUFA, the increase being in the VLDL and low-density lipoprotein (LDL) fractions. Our data thus indicate that elevation of VLDL- and LDL-cholesterol in hamsters by n\u20133 PUFA, compared with n\u20136 PUFA, is dependent on 0.5% dietary cholesterol supplementation. In rats, on the other hand, dietary n\u20133 PUFA did not induce hypercholesterolemia more than n\u20136 PUFA when 0.5% cholesterol was supplemented. Although the effects of n\u20133 PUFA on plasma cholesterol, triglycerides and VLDL-triglycerides were similar in hamsters and rats, the interactive effects of n\u20133 PUFA and cholesterol on plasma and lipoprotein cholesterol levels differed in the two species. It was also found that plasma triglycerides, cholesterol and lipoprotein cholesterol levels in hamsters are higher than in rats in the presence and absence of dietary cholesterol. In addition, cholesterol feeding induces hypertriglyceridemia and hypercholesterolemia only in hamsters. Moreover, liver triglyceride concentrations increased in rats fed a cholesterol-rich diet and hepatic triglyceride levels of the n\u20133 PUFA-fed rats were significantly lower than those in the n\u20136 PUFA-fed rats in the presence and absence of dietary cholesterol. However, triglycerides did not accumulate in the liver in hamsters fed a cholesterol-rich diet and hepatic triglyceride levels of the n\u20133 PUFA-fed hamsters were not significantly different from those in the n\u20136 PUFA-fed hamsters in the presence and absence of dietary cholesterol. Therefore, these studies confirm marked species differences in response to the interactive effects of dietary n\u20133 PUFA and cholesterol.<\/jats:p>","DOI":"10.1159\/000088891","type":"journal-article","created":{"date-parts":[[2005,10,14]],"date-time":"2005-10-14T08:09:01Z","timestamp":1129277341000},"page":"386-391","source":"Crossref","is-referenced-by-count":11,"title":["A High-Cholesterol, n\u20133 Polyunsaturated Fatty Acid Diet Causes Different Responses in Rats and Hamsters"],"prefix":"10.1159","volume":"49","author":[{"given":"Mei-Huei","family":"Lin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shao-Chun","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Po-Chao","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young-Chau","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shyun-Yeu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2005,12,9]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1159%2F000081199"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1159%2F000082250"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1079%2FBJN20031056"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1074%2Fjbc.M008809200"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1023%2FA%3A1007117321466"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2FS0955-2863%2803%2900101-3"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1194%2Fjlr.M300172-JLR200"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2F0026-0495%2894%2990096-5"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.83.6.1916"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1172%2FJCI112460"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1007%2FBF02537027"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2FS0952-3278%2896%2990039-3"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2FS0378-4347%2800%2982516-5"}],"container-title":["Annals of Nutrition and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/88891","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/88891","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:34:02Z","timestamp":1745465642000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000088891"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005]]},"references-count":13,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2005,12,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000088891","archive":["Portico"],"relation":{},"ISSN":["0250-6807","1421-9697"],"issn-type":[{"value":"0250-6807","type":"print"},{"value":"1421-9697","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005]]}}}