{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T08:38:02Z","timestamp":1791189482973,"version":"4.1.0"},"reference-count":27,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2005,12,7]],"date-time":"2005-12-07T00:00:00Z","timestamp":1133913600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2005,12,7]],"date-time":"2005-12-07T00:00:00Z","timestamp":1133913600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacology"],"published-print":{"date-parts":[[2006]]},"abstract":"<jats:p>Infusion of Fe&lt;sup&gt;2+&lt;\/sup&gt;, A\u03b2&lt;sub&gt;42&lt;\/sub&gt;, and buthionine-sulfoximine (FAB), but not A\u03b2&lt;sub&gt;42&lt;\/sub&gt; alone or in combination with Fe&lt;sup&gt;2+&lt;\/sup&gt;, into the left cerebral ventricle of Long-Evans rats for 4 weeks induced memory impairment that was accompanied by increased hyperphosphorylated Tau protein levels in the CSF. FAB-infused animals displayed thioflavin-S-positive amyloid deposits, hyperphosphorylated Tau protein, neuronal loss, and gliosis. Animals treated with A\u03b2&lt;sub&gt;42&lt;\/sub&gt;, Fe&lt;sup&gt;2+&lt;\/sup&gt;, or buthionine-sulfoximine alone or in combination failed to show the histological modifications seen with FAB. This data suggests that A\u03b2&lt;sub&gt;42&lt;\/sub&gt; is not sufficient to induce an Alzheimer\u2019s disease-like symptomatology, and it supports a model whereby a decrease in the brain\u2019s antioxidant defense system leads to the A\u03b2&lt;sub&gt;42&lt;\/sub&gt;-independent oxidative stress necessary for the peptide to induce histopathological changes and memory loss.<\/jats:p>","DOI":"10.1159\/000088929","type":"journal-article","created":{"date-parts":[[2005,10,14]],"date-time":"2005-10-14T08:09:01Z","timestamp":1129277341000},"page":"19-33","source":"Crossref","is-referenced-by-count":50,"title":["Beta-Amyloid and Oxidative Stress Jointly Induce Neuronal Death, Amyloid Deposits, Gliosis, and Memory Impairment in the Rat Brain"],"prefix":"10.1159","volume":"76","author":[{"given":"Laurent","family":"Lecanu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet","family":"Greeson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vassilios","family":"Papadopoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2005,12,7]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1126%2Fscience.1566067"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2F0197-4580%2887%2990073-X"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002%2Fana.410310202"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2F0197-4580%2890%2990119-K"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1038%2F27351"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1471-4159.1998.70052212.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2FS0304-3940%2800%2901449-X"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1177%2F019262330002800109"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.2337%2Fdiabetes.40.11.1375"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1038%2F35003235"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2990.2002.t01-2-00427.x"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00702-002-0763-y"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007%2Fs002210000561"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016%2FS0361-9230%2899%2900196-3"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016%2F0304-3940%2894%2990239-9"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1007%2Fs007020170025"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016%2FS0022-510X%2898%2900092-6"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016%2FS0196-9781%2802%2900066-9"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1471-4159.1996.66051836.x"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1460-9568.1999.00408.x"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1254%2Fjjp.73.51"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016%2FS0197-4580%2897%2900154-1"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1358%2Fdnp.2002.15.7.840079"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1179%2F016164103101202057"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016%2FS0197-4580%2801%2900300-1"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.95.11.6448"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.steroids.2003.09.007"}],"container-title":["Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/88929","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/88929","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:34:18Z","timestamp":1745465658000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000088929"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,12,7]]},"references-count":27,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2005,12,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000088929","archive":["Portico"],"relation":{},"ISSN":["0031-7012","1423-0313"],"issn-type":[{"value":"0031-7012","type":"print"},{"value":"1423-0313","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,12,7]]}}}