{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T05:28:41Z","timestamp":1791437321124,"version":"4.3.3"},"reference-count":15,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"published-print":{"date-parts":[[2006]]},"abstract":"<i>Background:<\/i> Erysipelas is a bacterial infection of the dermis and hypodermis, mostly of streptococcal origin. Bullous erysipelas represents a severe form of the disease. <i>Objective:<\/i> To evaluate the clinical and microbiological characteristics and treatment of bullous erysipelas. <i>Methods:<\/i> Patients with a diagnosis of bullous erysipelas who were treated at the Department of Dermatology, University Hospital of Heraklion, Crete, Greece, between the years 1996 and 2001 were retrospectively studied. <i>Results:<\/i> Fourteen patients (11 women, 3 men) with bullous erysipelas were evaluated. The lesions were located on the legs and face in 9 and 4 patients, respectively. The median duration of disease before hospital admission was 4 days. Eight patients had fever at presentation. Local trauma and various lesions were common causes for pathogen entry. The initial empirical antibiotic treatment included intravenous \u03b2-lactams and was modified according to the sensitivities of the isolated strains. <i>Staphylococcus aureus<\/i> was isolated from 7 (50%), while <i>S. warneri<\/i>, <i>Streptococcus pyogenes<\/i> and <i>Escherichia coli<\/i> grew from the lesions of 3 other patients. Six out of 7 <i>S. aureus<\/i> strains were methicillin resistant (MRSA) but susceptible to several other non-\u03b2-lactam antibiotics such as quinolones, vancomycin, rifampicin and trimethoprim\/sulfamethoxazole. <i>Conclusion:<\/i> Our findings suggest that <i>S. aureus<\/i> is frequently involved in and probably contributes in synergy with \u03b2-hemolytic streptococci to the complicated course of bullous erysipelas. The frequency of MRSA isolation suggests that \u03b2-lactam antibiotics may not be sufficient for the treatment of bullous erysipelas anymore, at least in areas with a high incidence of MRSA strains. The role of other classes of antibiotics providing adequate coverage for MRSA has to be evaluated in prospective clinical trials.<\/jats:p>","DOI":"10.1159\/000089019","type":"journal-article","created":{"date-parts":[[2005,11,30]],"date-time":"2005-11-30T14:46:43Z","timestamp":1133362003000},"page":"31-35","source":"Crossref","is-referenced-by-count":25,"title":["Bullous Erysipelas: Clinical Presentation, Staphylococcal Involvement and Methicillin Resistance"],"prefix":"10.1159","volume":"212","author":[{"given":"Konstantin","family":"Krasagakis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Samonis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panagiotis","family":"Maniatakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophia","family":"Georgala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Androniki","family":"Tosca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2006,1,20]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1001%2Farchderm.116.7.798"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1001%2Farchderm.125.6.779"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-4362.1990.tb04833.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1086%2F313467"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.3109%2F00365548609021656"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2FS0190-9622%2899%2970009-5"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1007%2Fs001050050004"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1159%2F000080853"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007%2FBF01646044"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1080%2F00365549850160945"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2FS0924-8579%2803%2900154-7"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2FS0924-8579%2803%2900055-4"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1001%2Fjama.290.22.2976"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jaad.2003.06.005"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jaad.2003.12.043"}],"container-title":["Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/89019","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/89019","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:35:45Z","timestamp":1745465745000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000089019"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006]]},"references-count":15,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2005,11,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000089019","archive":["Portico"],"relation":{},"ISSN":["1018-8665","1421-9832"],"issn-type":[{"value":"1018-8665","type":"print"},{"value":"1421-9832","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006]]}}}