{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T22:15:48Z","timestamp":1767824148259,"version":"3.49.0"},"reference-count":8,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"published-print":{"date-parts":[[2006]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Bullous mastocytosis is an unusual variant of mast cell disease with widespread bullae as the main cutaneous feature induced by mast cell proteases that cause dermoepidermal separation. &lt;i&gt;Case Report:&lt;\/i&gt; A rare case of diffuse cutaneous bullous mastocytosis with pachydermia and unusually extensive skin folding is described in a 3-week-old girl. The diagnosis was confirmed by immunohistochemistry with Giemsa stain, the naphthol ASD chloroacetate esterase reaction and elevated blood levels for tryptase, histamine in serum and histamine and 1.4-methylimidazol acetic acid in the 24-hour urine. Blood cell count was normal, as were thrombocytosis and leukocytosis. FACS analysis of the bone marrow aspiration material showed 1% mast cells. No c-Kit 816 [Asp\u2192Val] somatic mutation was found. Systemic involvement of other organs was excluded. &lt;i&gt;Discussion:&lt;\/i&gt; The prognosis of c-Kit-negative diffuse bullous mastocytosis is not known. Regular blood controls are mandatory, and screening for germ cell ovarian cancer and bone marrow controls should be performed as well.<\/jats:p>","DOI":"10.1159\/000089026","type":"journal-article","created":{"date-parts":[[2005,11,30]],"date-time":"2005-11-30T14:46:43Z","timestamp":1133362003000},"page":"70-72","source":"Crossref","is-referenced-by-count":17,"title":["Neonatal Mastocytosis with Pachydermic Bullous Skin without c-Kit 816 Mutation"],"prefix":"10.1159","volume":"212","author":[{"given":"T.","family":"Walker","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"von Komorowski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Scheurlen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Dorn-Beineke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Back","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Bayerl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2006,1,20]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2FS0889-8588%2803%2900089-3"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2FS0145-2126%2801%2900038-8"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1525-1470.2000.01751.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM199305063281803"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1038%2Fng0396-312"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2FS0889-8588%2805%2970299-9"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1080%2F1042819021000037967"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2133.2001.04322.x"}],"container-title":["Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/89026","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/89026","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:35:51Z","timestamp":1745465751000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000089026"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006]]},"references-count":8,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2005,11,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000089026","archive":["Portico"],"relation":{},"ISSN":["1018-8665","1421-9832"],"issn-type":[{"value":"1018-8665","type":"print"},{"value":"1421-9832","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006]]}}}