{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T20:03:35Z","timestamp":1785873815988,"version":"3.56.0"},"reference-count":33,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"published-print":{"date-parts":[[2006]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Various cytokines are reportedly associated with many neonatal diseases. Asphyxia is considered to result in ischemia-reperfusion injuries and induces abnormal inflammatory responses involving excessive cytokine production. &lt;i&gt;Objectives:&lt;\/i&gt; To evaluate alteration in sera levels of various cytokines\/chemokines in case of perinatal asphyxia at birth. &lt;i&gt;Methods:&lt;\/i&gt; In orderto determine the concentrations of various cytokines\/chemokines in sera, we used a highly sensitive fluorescence microsphere method. We measured the concentration of 8 types of cytokines\/chemokines in sera obtained from 17 cases of asphyxia, 10 normal neonates, and 6 healthy adults. &lt;i&gt;Results:&lt;\/i&gt; The concentrations of IL-6, IL-8, and IL-10 in the sera of asphyxiated neonates were higher than those in the normal neonates. Irrespective of the presence or absence of asphyxia, sera concentrations of IL-2, IL-4, IFN-\u03b3, and TNF-\u03b1 were higher in the neonates than those in the adults. The concentration of IFN-\u03b3 in the asphyxiated neonates was lower than that in the normal neonates. Sera levels of IL-10 were higher in the asphyxiated cases than those in the normal neonates. The sera levels of IL-6, IL-8, and IL-10 in asphyxiated neonates with either a poor outcome or death were higher than those without poor outcomes. &lt;i&gt;Conclusions:&lt;\/i&gt; The concentrations of various types of cytokines\/chemokines were different in neonatal sera and some of them increased drastically during asphyxia. The concentration of an anti-inflammatory cytokine IL-10 was elevated in asphyxiated neonates immediately after birth, thereby suggesting that IL-10 might be associated with neuroprotective functions.<\/jats:p>","DOI":"10.1159\/000089180","type":"journal-article","created":{"date-parts":[[2005,10,24]],"date-time":"2005-10-24T08:16:59Z","timestamp":1130141819000},"page":"183-189","source":"Crossref","is-referenced-by-count":39,"title":["Elevation of Cytokine Concentrations in Asphyxiated 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