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Karger AG","issue":"Suppl. 1","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"published-print":{"date-parts":[[2006]]},"abstract":"<jats:p>After preoperative conjunctival and periorbital antisepsis with povidone-iodine (PVP-I), the systemic absorption of iodine after cataract surgery was measured to evaluate the risk of thyroid side effects. Five different combinations of PVP-I alone or in combination with PVP-I-free antiseptics were applied to the conjunctiva and periorbital skin. An iodine-free product served as control. Iodide and creatinine in urine were analyzed before intervention and 24 and 48 h postoperatively. Depending on the concentration and application site, 0.3\u20134.5% of the total applied iodine or 3.6\u201345.4% of the free iodine were absorbed. The range of urine iodine excretion was between 11.7 and 71.0 \u00b5g iodine\/g creatinine, depending on the PVP-I concentration and the site of application. The increase in iodine excretion was significant at 24 h postoperatively in trials receiving PVP-I both periorbitally and conjunctivally, depending of the concentration used. Because the iodine absorption is only slight and of doubtful clinical relevance, presurgical conjunctival antisepsis can be achieved with 1.25% PVP-I; so far clinically manifest anamnestic thyroid disorders are excluded. Presently, periorbital skin antisepsis with PVP-I cannot be recommended until data on thyroid metabolism in the population have been collected and evaluated, especially in a region currently or previously deficient in iodine.<\/jats:p>","DOI":"10.1159\/000089198","type":"journal-article","created":{"date-parts":[[2006,2,21]],"date-time":"2006-02-21T07:42:29Z","timestamp":1140507749000},"page":"41-46","source":"Crossref","is-referenced-by-count":18,"title":["Systemic Iodine Absorption after Preoperative Antisepsis Using Povidone-Iodine in Cataract Surgery \u2013 An Open Controlled Study"],"prefix":"10.1159","volume":"212","author":[{"given":"H.","family":"Below","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Behrens-Baumann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Bernhardt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"V\u00f6lzke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Kramer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Rudolph","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2006,2,22]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1159%2F000057733"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2FS0002-9394%2802%2901701-4"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00347-003-0933-9"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1007%2Fs003470050294"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007%2Fs003470050471"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2FS0002-9394%2802%2901701-4"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1007%2Fs003470170174"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2FS0009-2797%2803%2900059-0"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1055%2Fs-0029-1212050"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1089%2F105072503768499680"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1089%2Fthy.1998.8.83"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1021%2Fja01321a510"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007%2FBF01476194"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1055%2Fs-2007-1024418"}],"container-title":["Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/89198","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/89198","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:37:38Z","timestamp":1745465858000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000089198"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006]]},"references-count":14,"journal-issue":{"issue":"Suppl. 1","published-online":{"date-parts":[[2006,2,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000089198","archive":["Portico"],"relation":{},"ISSN":["1018-8665","1421-9832"],"issn-type":[{"type":"print","value":"1018-8665"},{"type":"electronic","value":"1421-9832"}],"subject":[],"published":{"date-parts":[[2006]]}}}