{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T04:10:45Z","timestamp":1745554245839,"version":"3.40.4"},"reference-count":19,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncology"],"published-print":{"date-parts":[[2005]]},"abstract":"<i>Background:<\/i> Induction chemotherapy followed by surgical resection or definitive radiotherapy for patients affected by stage IIIA N2 bulky non-small cell lung cancer (NSCLC) has been investigated in several trials. <i>Patients and Methods:<\/i> In this present study, 52 patients with stage IIIA N2 bulky NSCLC with cytologically or histologically confirmed mediastinal lymph node involvement received paclitaxel 175 mg\/mq on day 1, carboplatin AUC 5 on day 1 and gemcitabine 1,000 mg\/mq on day 1 and 8 every 3 weeks for three cycles as induction chemotherapy. <i>Results:<\/i> Objective response (4 complete remission and 36 partial remission) was achieved in 40\/52 patients. No early or toxic deaths were observed. Twenty-two patients were surgically explored. Fifteen were excluded for resection for biopsy-proven residual tumour in mediastinal nodes. Complete surgical resection was performed in 15 patients with confirmed pathological downstaging. Pathological complete response was achieved in 4 patients. No surgery-related mortality or significant morbidity was reported. Adjuvant radiotherapy was delivered in 15 patients, and 30 patients received definitive radiotherapy. <i>Conclusion:<\/i> In the present study, the combination of paclitaxel, carboplatin and gemcitabine has been a safe and active regimen in poor-prognosis stage IIIA N2 bulky NSCLC.<\/jats:p>","DOI":"10.1159\/000089679","type":"journal-article","created":{"date-parts":[[2005,11,11]],"date-time":"2005-11-11T07:43:11Z","timestamp":1131694991000},"page":"295-300","source":"Crossref","is-referenced-by-count":3,"title":["Paclitaxel, Carboplatin and Gemcitabine Combination as Induction Chemotherapy for Stage IIIA N2 Bulky Non-Small Cell Lung Cancer"],"prefix":"10.1159","volume":"69","author":[{"given":"Giorgio Carmelo","family":"Giannitto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dario","family":"Giuffrida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Pappalardo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Russo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno","family":"Vincenzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salvino","family":"Saita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrico","family":"Potenza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franco","family":"Marletta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"La Venia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio","family":"Castorina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Bordonaro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2005,12,5]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.3322%2Fcanjclin.47.1.5"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2F0003-4975%2893%2991072-U"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2FS0169-5002%2897%2900658-2"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2F0003-4975%2892%2990373-C"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1093%2Fjnci%2F86.9.673"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM199401203300301"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2FS0169-5002%2899%2900045-8"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2FS0169-5002%2898%2900046-4"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2F0197-2456%2889%2990015-9"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.2307%2F2281868"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1067%2Fmtc.2003.15"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1200%2FJCO.20.1.247"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1002%2F1097-0142%2819950815%2976%3A4%3C593%3A%3AAID-CNCR2820760409%3E3.0.CO%3B2-N"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1093%2Fjnci%2F88.17.1210"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1093%2Fjnci%2F87.3.198"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1093%2Fjnci%2F83.6.417"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016%2FS0959-8049%2803%2900319-8"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291097-0142%2819990315%2985%3A6%3C1269%3A%3AAID-CNCR8%3E3.0.CO%3B2-I"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1023%2FA%3A1026527004596"}],"container-title":["Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/89679","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/89679","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:43:14Z","timestamp":1745466194000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000089679"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005]]},"references-count":19,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2005,11,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000089679","archive":["Portico"],"relation":{},"ISSN":["0030-2414","1423-0232"],"issn-type":[{"type":"print","value":"0030-2414"},{"type":"electronic","value":"1423-0232"}],"subject":[],"published":{"date-parts":[[2005]]}}}