{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:10:05Z","timestamp":1745467805206,"version":"3.40.4"},"reference-count":19,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"published-print":{"date-parts":[[2006]]},"abstract":"<jats:p>Insulin-like growth factor (IGF)-I is a polypeptide that mediates the growth-promoting action of growth hormone in postnatal animals. The present study was conducted to examine whether orally administered IGF-I would be absorbed into the general circulation and also whether ingested IGF-I would enhance the growth of whole body as well as internal organs, and tissues in 3-week-old ICR-strain female weanling mice. In experiment (Exp) 1, a total of 70 mice received IGF-I orally at 1 \u00b5g\u00b7g&lt;sup&gt;\u20131&lt;\/sup&gt; in 0.2-ml PBS or the vehicle alone. Concentrations of IGF-I and glucose in heart blood were measured after killing 5 animals in each group every fourth hour during a 24-hour period. In Exp 2, a total of 40 mice received oral IGF-I administration at 1 \u00b5g\u00b7g&lt;sup&gt;\u20131&lt;\/sup&gt; or vehicle every third day beginning from day 0 for a 13-day period. Half the animals were killed at day 7 and the other half at day 13. Weights of whole body and organs\/tissues (small intestine, liver, thigh muscle, and brain) were measured every day and at slaughter, respectively. In Exp 1, following the oral IGF-I administration, serum IGF-I concentration increased at hour 4 (p &lt; 0.01) and returned to the hour 0 level by hour 8, whereas glucose concentration was lowest at hour 4 and returned to the hour 0 level by hour 16. In the PBS-fed group, neither IGF-I nor glucose concentration changed during the 24-hour period. In Exp 2, weight of small intestine increased (p &lt; 0.05) in response to the oral IGF-I, whereas weights of liver and thigh muscle of the IGF-I-fed group were greater (p &lt; 0.01) and tended to be greater (p = 0.06), respectively, than those of the PBS-fed only at day 13. However, brain weight and serum concentrations of IGF-I and IGF-II were not affected by oral IGF-I administration. Results suggest that although orally administered IGF-I mainly acts at the intestine, a portion of ingested IGF-I is absorbed into the general circulation to enhance the growth of selective organs\/tissues in weanling mice.<\/jats:p>","DOI":"10.1159\/000089796","type":"journal-article","created":{"date-parts":[[2006,2,2]],"date-time":"2006-02-02T09:34:37Z","timestamp":1138872877000},"page":"199-204","source":"Crossref","is-referenced-by-count":9,"title":["Effects of Oral Administration of Insulin-Like Growth Factor-I on Circulating Concentration of Insulin-Like Growth Factor-I and Growth of Internal Organs in Weanling Mice"],"prefix":"10.1159","volume":"89","author":[{"given":"W.K.","family":"Kim","sequence":"first","affiliation":[]},{"given":"Y.H.","family":"Ryu","sequence":"additional","affiliation":[]},{"given":"D.S.","family":"Seo","sequence":"additional","affiliation":[]},{"given":"C.Y.","family":"Lee","sequence":"additional","affiliation":[]},{"given":"Y.","family":"Ko","sequence":"additional","affiliation":[]}],"member":"127","published-online":{"date-parts":[[2006,4,6]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.3109%2F08977199109000267"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1210%2Fer.16.1.3"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1210%2Fen.140.11.5178"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1210%2Fer.22.1.53"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2F0014-2999%2886%2990093-2"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1677%2Fjoe.0.1370413"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1006%2Fgcen.1998.7072"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1677%2Fjoe.0.1440091"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1136%2Fgut.37.5.630"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1210%2Fen.136.11.4880"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1074%2Fjbc.270.20.12109"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1097%2F00005176-199611000-00013"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.3109%2F08977199709021512"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1203%2F00006450-200010000-00013"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016%2FS0024-3205%2897%2900357-3"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291099-0895%28199610%2912%3A3%3C195%3A%3AAID-DMR164%3E3.3.CO%3B2-7"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1210%2Fer.14.6.710"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1203%2F00006450-199101000-00010"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1203%2F00006450-199505000-00005"}],"container-title":["Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/89796","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/89796","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:44:40Z","timestamp":1745466280000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000089796"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006]]},"references-count":19,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2006,4,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000089796","archive":["Portico"],"relation":{},"ISSN":["1661-7800","1661-7819"],"issn-type":[{"type":"print","value":"1661-7800"},{"type":"electronic","value":"1661-7819"}],"subject":[],"published":{"date-parts":[[2006]]}}}