{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T18:41:23Z","timestamp":1776883283706,"version":"3.51.2"},"reference-count":15,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respiration"],"published-print":{"date-parts":[[2006]]},"abstract":"<i>Background:<\/i> Plant-based medicine is the 3rd most popular choice of both adults (11%) and children (6%) suffering from Asthma. While several plant-based formulations have been reported for the treatment of asthma in the past, many authors have published their reservations on clinical trials carried out using complementary and alternative medicines. <i>Objectives:<\/i> The authors desired to eliminate the shortcomings of the earlier clinical trials carried out by many investigators in a structured study. Therefore, a 12-week randomized double-blind placebo-controlled clinical study was conducted to investigate the efficacy of a plant-based formulation (DCBT4567-Astha-15) in comparison with oral salbutamol, salbutamol + theophylline and a matching placebo in patients with reversible asthma. <i>Methods:<\/i> Ninety-four patients between 15 and 50 years of age, showing 15% improvement in forced expiratory volume in 1 s (FEV<sub>1<\/sub>) 15 min after a bronchial challenge of inhaled salbutamol (200 \u00b5g) were recruited, and the end point of the study was determined as a 15% improvement in FEV<sub>1<\/sub> and clinical symptoms like dyspnoea, wheezing, cough, expectoration, disability, sleep disturbances and respiration rate. <i>Results:<\/i> DCBT4567-Astha-15, salbutamol and salbutamol + theophylline patients showed statistically significant improvement in FEV<sub>1<\/sub>, while placebo patients did not show any improvement. Fifty percent of DCBT4567-Astha-15, 48% of salbutamol, 58% of salbutamol + theophylline and 26% of placebo patients showed the desired 15% improvement in FEV<sub>1<\/sub>. Improved mean FEV<sub>1<\/sub> values at the end of the trial indicated that the salbutamol - theophylline combination was superior followed by salbutamol and DCBT4567-Astha-15. Clinical symptoms like dyspnoea, wheezing, cough, expectoration, disability, and sleep disturbances were significantly reduced in DCBT4567-Astha-15 patients compared to patients of the other three arms. <i>Conclusions:<\/i> DCBT4567-Astha-15 was as efficacious as salbutamol (12 mg\/day) or salbutamol (12 mg\/day) in combination with theophylline (200 mg\/day) in the treatment of reversible asthmatics. Quality of life of patients also improved with DCBT4567-Astha-15 drug treatment.<\/jats:p>","DOI":"10.1159\/000089922","type":"journal-article","created":{"date-parts":[[2005,11,23]],"date-time":"2005-11-23T10:27:31Z","timestamp":1132741651000},"page":"457-463","source":"Crossref","is-referenced-by-count":12,"title":["Plant-Based Formulation for Bronchial Asthma: A Controlled Clinical Trial to Compare Its Efficacy with Oral Salbutamol and Theophylline"],"prefix":"10.1159","volume":"73","author":[{"given":"P.M.","family":"Murali","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Rajasekaran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.R.","family":"Krishnarajasekar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Perumal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Nalini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Lakshmisubramanian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.N.","family":"Deivanayagam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2006,7,5]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2F0091-6749%2891%2992135-N"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1159%2F000068419"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.3109%2F02770909809048969"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1159%2F000029274"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1136%2Fthorax.55.11.925"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1093%2Fije%2F30.3.526"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM199605233342107"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.3109%2F08820139909062263"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2FS0378-8741%2899%2900181-6"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2F0378-8741%2886%2990025-5"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2F0952-3278%2891%2990070-L"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2F0003-9861%2892%2990040-4"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2F0378-8741%2891%2990017-8"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016%2F0885-4505%2887%2990023-5"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1038%2F1841317a0"}],"container-title":["Respiration"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/89922","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/89922","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:38:42Z","timestamp":1745462322000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000089922"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006]]},"references-count":15,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2006,6,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000089922","archive":["Portico"],"relation":{},"ISSN":["0025-7931","1423-0356"],"issn-type":[{"value":"0025-7931","type":"print"},{"value":"1423-0356","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006]]}}}