{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T21:08:07Z","timestamp":1789679287548,"version":"4.0.1"},"reference-count":16,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ophthalmic Res"],"published-print":{"date-parts":[[2006]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Surgically induced necrotizing scleritis is primarily managed with immunosuppressive regimens. Such treatments can alter inflammatory cytokines and products such as tumor necrosis factor-\u03b1 (TNF-\u03b1) and matrix metalloproteinase-9 (MMP-9), which are an important proinflammatory cytokine and a tissue-degrading protease involved in necrosis of some ocular tissues. &lt;i&gt;Object:&lt;\/i&gt; To evaluate TNF-\u03b1 and MMP-9 in the tear or sclera of surgically induced necrotizing scleritis. &lt;i&gt;Methods:&lt;\/i&gt; After tear collection from healthy and diseased eyes of 2 patients, immunoblot analysis using monoclonal antibody specific for human TNF-\u03b1 and MMP-9 was performed. In another patient, scleral tissues were obtained during scleral allograft surgery, and the same immunoblot analysis was done. &lt;i&gt;Results:&lt;\/i&gt; The level of TNF-\u03b1 and MMP-9 was increased in tear fluid from patients compared to that of control volunteers and returned to the control level after treatment. The diseased sclera showed an increased expression of MMP-9 compared to that of the normal donor sclera. &lt;i&gt;Conclusions:&lt;\/i&gt; TNF-\u03b1 and MMP-9 may suggest disease activity of surgically induced necrotizing scleritis and can be altered by proper immunosuppressive treatment.<\/jats:p>","DOI":"10.1159\/000090010","type":"journal-article","created":{"date-parts":[[2005,11,30]],"date-time":"2005-11-30T14:46:43Z","timestamp":1133362003000},"page":"66-70","source":"Crossref","is-referenced-by-count":27,"title":["Expression of Tumor Necrosis Factor Alpha and Matrix Metalloproteinase-9 in Surgically Induced Necrotizing Scleritis"],"prefix":"10.1159","volume":"38","author":[{"given":"Kyoung Yul","family":"Seo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyung Keun","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eung Kweon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joon H.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2006,3,1]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1136%2Fbjo.76.1.17"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1136%2Fbjo.84.9.1050"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1097%2F00003226-200305000-00002"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1097%2F00003226-199707000-00013"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1038%2F227680a0"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1136%2Fbjo.87.5.548"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1006%2Fexer.2001.1054"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2FS0021-5155%2803%2900138-2"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1167%2Fiovs.02-0565"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.exer.2003.12.005"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1167%2Fiovs.04-0299"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2FS0002-9394%2801%2900913-8"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.4321%2FS0365-66912004000800010"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.eye.6701457"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016%2FS0161-6420%2803%2900721-8"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ajo.2004.06.077"}],"container-title":["Ophthalmic Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/90010","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/90010","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:39:46Z","timestamp":1745462386000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000090010"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006]]},"references-count":16,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2006,2,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000090010","archive":["Portico"],"relation":{},"ISSN":["0030-3747","1423-0259"],"issn-type":[{"value":"0030-3747","type":"print"},{"value":"1423-0259","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006]]}}}