{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T12:25:00Z","timestamp":1745756700898,"version":"3.40.4"},"reference-count":17,"publisher":"S. Karger AG","issue":"5-6","license":[{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Kidney Blood Press Res"],"published-print":{"date-parts":[[2005]]},"abstract":"<i>Background:<\/i> According to new guidelines, diabetes mellitus <i>per se<\/i> can be considered as stage I chronic heart failure (CHF). Available evidence suggests that patients suffering from both diabetes mellitus and renal insufficiency have disproportionately high rates of left-ventricular hypertrophy (LVH). <i>Methods:<\/i> Optimized heart failure therapy, including \u03b2-blockers, ACE-inhibitors and AT II-type-1-receptor-blockers, was prescribed in combination with complete anemia correction using epoetin beta (target hemoglobin: 13.5 g\/dl for women; 14.5 g\/dl for men) to 230 patients (55% male) with ambulatory hemodialysis, including 60 patients (52% male) with diabetes. Echocardiographic follow-up examinations were performed over a mean period of 4.4 \u00b1 1.2 years. <i>Results:<\/i> Mean hemoglobin levels at the study end significantly increased to target levels in the entire study population and in patients with diabetes (both p < 0.001). Compared with baseline, significant improvements were seen in hemodialysis patients \u2013 both without and with diabetes \u2013 in left-ventricular mass index (\u201328.8 g\/m<sup>2<\/sup> [p < 0.001] and 29.0 g\/m<sup>2<\/sup> [p < 0.005], respectively), left-ventricular ejection fraction (+7.0% [p < 0.001] and +8.3% [p < 0.01], respectively) and in NYHA class (\u20130.84 [p < 0.01] and \u20131.12 [p < 0.01], respectively). Similar to the results in the overall population, a highly significant reduction in LVH (p < 0.005) and significant improvements in LVEF (p < 0.01) and NYHA class (p < 0.01) were seen in the high-risk subgroup of diabetic patients. <i>Conclusions:<\/i> Patients undergoing hemodialysis, with or without concomitant diabetes, benefit considerably from optimized, multifactorial heart failure therapy combined with complete anemia correction.<\/jats:p>","DOI":"10.1159\/000090190","type":"journal-article","created":{"date-parts":[[2006,3,8]],"date-time":"2006-03-08T10:21:57Z","timestamp":1141813317000},"page":"353-362","source":"Crossref","is-referenced-by-count":5,"title":["Optimized Heart Failure Therapy and Complete Anemia Correction on Left-Ventricular Hypertrophy in Nondiabetic and Diabetic Patients Undergoing Hemodialysis"],"prefix":"10.1159","volume":"28","author":[{"given":"Hannelore","family":"Hampl","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars","family":"Hennig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Rosenberger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lutz","family":"Gogoll","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eberhard","family":"Riedel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Armin","family":"Scherhag","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2006,3,20]]},"reference":[{"doi-asserted-by":"publisher","key":"ref1","DOI":"10.2337%2Fdiacare.26.10.2941"},{"doi-asserted-by":"publisher","key":"ref2","DOI":"10.1038\/35093011"},{"doi-asserted-by":"publisher","key":"ref3","DOI":"10.1081%2FJCMR-120016387"},{"doi-asserted-by":"publisher","key":"ref4","DOI":"10.1177%2F000331970005100703"},{"doi-asserted-by":"publisher","key":"ref5","DOI":"10.1055%2Fs-2008-1043134"},{"doi-asserted-by":"publisher","key":"ref6","DOI":"10.1038\/331168a0"},{"doi-asserted-by":"publisher","key":"ref7","DOI":"10.1159%2F000085881"},{"doi-asserted-by":"publisher","key":"ref8","DOI":"10.1126\/science.285.5429.882"},{"doi-asserted-by":"publisher","key":"ref9","DOI":"10.1016%2FS0272-6386%2803%2900359-7"},{"doi-asserted-by":"publisher","key":"ref10","DOI":"10.1097%2F00000441-200304000-00004"},{"doi-asserted-by":"publisher","key":"ref11","DOI":"10.1046%2Fj.1464-5491.2002.00634.x"},{"doi-asserted-by":"publisher","key":"ref12","DOI":"10.1093%2Fndt%2F15.7.964"},{"doi-asserted-by":"publisher","key":"ref13","DOI":"10.1056%2FNEJM199808273390903"},{"doi-asserted-by":"publisher","key":"ref14","DOI":"10.1056%2FNEJM199809173391203"},{"doi-asserted-by":"publisher","key":"ref15","DOI":"10.1007%2Fs003950050240"},{"doi-asserted-by":"publisher","key":"ref16","DOI":"10.1097%2F00004872-200305000-00011"},{"doi-asserted-by":"publisher","key":"ref17","DOI":"10.1159%2F000080241"}],"container-title":["Kidney and Blood Pressure Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/90190","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/90190","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:41:32Z","timestamp":1745462492000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000090190"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005]]},"references-count":17,"journal-issue":{"issue":"5-6","published-online":{"date-parts":[[2006,3,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000090190","archive":["Portico"],"relation":{},"ISSN":["1420-4096","1423-0143"],"issn-type":[{"type":"print","value":"1420-4096"},{"type":"electronic","value":"1423-0143"}],"subject":[],"published":{"date-parts":[[2005]]}}}