{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T10:29:53Z","timestamp":1761647393472,"version":"3.40.4"},"reference-count":12,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Neurol"],"published-print":{"date-parts":[[2005]]},"abstract":"<jats:p>Neuropathological studies of hereditary spastic paraparesis (HSP) have described axonal loss involving corticospinal and somatosensory tracts in the spinal cord. This MRI-based study was intended to investigate in vivo diameter alterations of the spinal cord in HSP, including both pure HSP (p-HSP, n = 20) and complicated HSP (c-HSP, n = 10). Standard MRI examinations of the cervical and thoracic spinal cord in HSP patients and a control group (n = 54) were analyzed by standardized spinal cord planimetry. In HSP patients, significant atrophy of the upper spinal cord compared to controls was observed at p&lt;0.001 both at the cervical and at the thoracic level. Myelon diameters at both levels were also significantly reduced in the two HSP subgroups in an additional comparison with age-matched subgroups of controls each, but p-HSP and c-HSP groups themselves did not differ. Marked atrophy of the upper spinal cord seems to be associated with HSP, assumedly due to the central-distal axonopathy. However, the differences between p-HSP and c-HSP could not be visualized by structural MRI at spinal cord level.<\/jats:p>","DOI":"10.1159\/000090294","type":"journal-article","created":{"date-parts":[[2006,2,7]],"date-time":"2006-02-07T10:08:18Z","timestamp":1139306898000},"page":"181-185","source":"Crossref","is-referenced-by-count":21,"title":["Magnetic Resonance Investigation of the Upper Spinal Cord in Pure and Complicated Hereditary Spastic Paraparesis"],"prefix":"10.1159","volume":"54","author":[{"given":"Anne-Dorte","family":"Sperfeld","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annette","family":"Baumgartner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Kassubek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2006,2,1]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1136%2Fjnnp.69.2.150"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1097%2F00019052-200108000-00005"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002%2Fana.20416"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1001%2Farchneur.60.8.1045"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2F0303-8467%2892%2990010-Z"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2990.2004.00587.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1136%2Fjnnp.64.1.61"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1159%2F000084650"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007%2FBF02224539"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1007%2Fs002340050495"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1001%2Farchneur.59.12.1921"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1007%2FBF02249105"}],"container-title":["European Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/90294","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/90294","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:42:29Z","timestamp":1745462549000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000090294"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005]]},"references-count":12,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2006,1,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000090294","archive":["Portico"],"relation":{},"ISSN":["0014-3022","1421-9913"],"issn-type":[{"type":"print","value":"0014-3022"},{"type":"electronic","value":"1421-9913"}],"subject":[],"published":{"date-parts":[[2005]]}}}