{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:51:29Z","timestamp":1787017889194,"version":"build-2736575974"},"reference-count":34,"publisher":"S. Karger AG","issue":"1-2","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dig Dis"],"published-print":{"date-parts":[[2006]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Triple therapy is the treatment of choice for &lt;i&gt;Helicobacter pylori&lt;\/i&gt;-infected patients with an eradication rate ranging from 70 to 85%. Poor compliance and antibiotic resistance are the main causes of treatment failure. The aim of the present study was to assess the efficacy of rifaximin, a poorly absorbed antibiotic, for &lt;i&gt;H. pylori&lt;\/i&gt; eradication. &lt;i&gt;Methods:&lt;\/i&gt; We enrolled 48 consecutive &lt;i&gt;H. pylori&lt;\/i&gt;-positive patients affected. They were randomized to receive two 7-day rifaximin-based triple therapies: rifaximin tablets 400 mg t.i.d., esomeprazole 40 mg o.d. and clarithromycin 500 mg b.i.d. (CRE) or levofloxacin 500 mg o.d. (LRE). &lt;i&gt;H. pylori&lt;\/i&gt; eradication was assessed using a &lt;sup&gt;13&lt;\/sup&gt;C-urea breath test 4 weeks after the end of therapy. Treatment compliance and the incidence of side effects were also evaluated. &lt;i&gt;Results:&lt;\/i&gt; No dropouts were observed. The eradication rate both on intention-to-treat and per-protocol analysis did not show significant differences between groups: 58% (14\/24 patients) in group 1 and 42% (10\/24 patients) in group 2 (p = 0.24, OR 1.96, 95% CI 0.62\u20136.18). No significant differences in patients\u2019 compliance and incidence of side effects were found between groups. &lt;i&gt;Conclusions:&lt;\/i&gt; Rifaximin-based therapy showed optimal compliance but a limited eradication rate compared to standard first-line treatment. Further investigations are needed to evaluate different dosages and combinations.<\/jats:p>","DOI":"10.1159\/000090330","type":"journal-article","created":{"date-parts":[[2006,5,26]],"date-time":"2006-05-26T09:49:21Z","timestamp":1148636961000},"page":"195-200","source":"Crossref","is-referenced-by-count":19,"title":["Rifaximin-Based Regimens for Eradication of &lt;i&gt;Helicobacter pylori&lt;\/i&gt;: A Pilot Study"],"prefix":"10.1159","volume":"24","author":[{"given":"Antonio","family":"Gasbarrini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ernesto Cristiano","family":"Lauritano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico 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