{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T08:58:58Z","timestamp":1790499538553,"version":"4.1.0"},"reference-count":28,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"published-print":{"date-parts":[[2006]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; In pemphigus, loss of epidermal adhesion is induced by binding of circulating autoantibodies to the desmosomal cadherins desmoglein 3 (Dsg3) in pemphigus vulgaris (PV) and desmoglein 1 (Dsg1) in pemphigus foliaceus (PF), respectively. Therapeutic removal of Dsg-reactive autoantibodies by immunoadsorption (IA) has been demonstrated to exert clinical remission of the disease. &lt;i&gt;Objectives:&lt;\/i&gt; The aim of this intervention study was to evaluate the efficacy and safety of the peptide-based Globaffin&lt;sup&gt;\u00ae&lt;\/sup&gt; adsorber system in the treatment of severe pemphigus cases. &lt;i&gt;Patients and Methods:&lt;\/i&gt; We applied IA in 4 PV and 2 PF patients with severe chronic disease resistant to conventional immunosuppressive therapy. IA was performed on 4 consecutive days, representing 1 treatment cycle, followed by a 4-week treatment-free interval. Serum samples for determining serum IgG and anti-Dsg1\/Dsg3 IgG autoantibodies were drawn daily before and after IA, respectively. During follow-up, patients were examined carefully, and laboratory parameters were controlled monthly for up to 1 year. &lt;i&gt;Results:&lt;\/i&gt; IA led to excellent clinical responses. Skin and mucosal lesions cleared almost completely within weeks. One IA cycle reduced anti-Dsg1 and anti-Dsg3 autoantibodies by an average of 50\u201370% as determined by ELISA. &lt;i&gt;Conclusions:&lt;\/i&gt; Using the Globaffin adsorber system, IA represents an effective and safe treatment opportunity in severe and therapy-resistant pemphigus.<\/jats:p>","DOI":"10.1159\/000090659","type":"journal-article","created":{"date-parts":[[2006,2,21]],"date-time":"2006-02-21T07:42:29Z","timestamp":1140507749000},"page":"177-187","source":"Crossref","is-referenced-by-count":48,"title":["Prolonged Clinical Remission of Patients with Severe Pemphigus upon Rapid Removal of Desmoglein-Reactive Autoantibodies by Immunoadsorption"],"prefix":"10.1159","volume":"212","author":[{"given":"R\u00fcdiger","family":"Eming","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen","family":"Rech","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Barth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joachim R.","family":"Kalden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerold","family":"Schuler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Harrer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Hertl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2006,3,15]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1159%2F000024364"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2F0092-8674%2891%2990360-B"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM198205203062001"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1172%2FJCI117349"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111%2F1523-1747.ep12606168"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2133.2002.04838.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.92.11.5239"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2133.2001.04228.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2133.1978.tb01631.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1001%2Farchderm.124.11.1702"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1067%2Fmjd.2000.109297"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1526-0968.2001.00360.x"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1136%2Fard.2003.011486"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1136%2Fard.2004.029660"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2133.2003.05302.x"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2133.2003.05513.x"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1523-1747.2002.19529.x"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1744-9987.1997.tb00037.x"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1526-0968.2003.00017.x"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1182%2Fblood-2002-01-0128"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1159%2F000057886"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1007%2FPL00006852"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1177%2F096120339500400607"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jaad.2003.08.021"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2133.2005.06651.x"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1526-0968.1999.00155.x"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1526-0968.2000.004004296.x"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1523-1747.1998.00086.x"}],"container-title":["Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/90659","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/90659","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:46:36Z","timestamp":1745462796000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000090659"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006]]},"references-count":28,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2006,2,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000090659","archive":["Portico"],"relation":{},"ISSN":["1018-8665","1421-9832"],"issn-type":[{"value":"1018-8665","type":"print"},{"value":"1421-9832","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006]]}}}