{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T16:53:16Z","timestamp":1791046396288,"version":"4.1.0"},"reference-count":16,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dement Geriatr Cogn Disord"],"published-print":{"date-parts":[[2006]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Although QOL is an important indicator to assess multiple facets of life, the QOL of Alzheimer\u2019s disease (AD) subjects with impaired cognitive ability due to dementia has not yet been fully investigated. In this study, we developed the Japanese version of the Quality of Life \u2013 Alzheimer\u2019s disease (QOL-AD) scale by means of back-translation, and ascertained its reliability and validity for evaluating the quality of life in AD subjects. We also hypothesized that the presence of neuropsychiatric symptoms may determine the characteristics and determinants of both the patients\u2019 and the caregivers\u2019 responses to the patients\u2019 QOL questionnaire. &lt;i&gt;Methods:&lt;\/i&gt; We administered the QOL-AD questionnaire to subjects with mild or moderate AD (n = 140). The test-retest reliability was evaluated by the same interviewer after a month\u2019s interval. Data from the following tests were also collected to ascertain the validity of the questionnaire: Short Memory Questionnaire (SMQ), Neuropsychiatry Inventory (NPI), Hyogo Activities of Daily Living Scale (HADL) and Mini-Mental State Examination (MMSE). &lt;i&gt;Results:&lt;\/i&gt; The Japanese version of the QOL-AD questionnaire demonstrated good internal reliability for both the patients\u2019 (Cronbach\u2019s \u03b1 = 0.84) and the caregivers\u2019 responses (Cronbach\u2019s \u03b1 = 0.82) and good test-retest reliability for both the patients\u2019 (intraclass correlation coefficient = 0.84) and caregivers\u2019 reports (intraclass correlation coefficient = 0.91). The concordance between the patients\u2019 self-report and the caregivers\u2019 observation was moderate (Pearson correlation coefficient = 0.60). The score for the \u2018mood factor\u2019 (apathy, depression\/dysphoria) in NPI predicted the overall QOL score as determined from both the patients\u2019 and the caregivers\u2019 responses for subjects with mild (MMSE\u226721, n = 88) and moderate (MMSE&lt;21, n = 52) AD. The score for the \u2018psychosis factor\u2019 (delusions, hallucinations, anxiety, agitation, disinhibition, irritability, aberrant motor activity) in NPI predicted the total QOL score as determined by the patients and the caregivers among subjects with moderate AD only. &lt;i&gt;Conclusions:&lt;\/i&gt; As hypothesized, the presence of neuropsychiatric symptoms may be an important predictor of both the patients\u2019 and caregivers\u2019 responses to the patients\u2019 QOL questionnaire. QOL-AD appears to be a promising measure of the QOL of subjects with mild to moderate AD in Japan.<\/jats:p>","DOI":"10.1159\/000090744","type":"journal-article","created":{"date-parts":[[2006,1,9]],"date-time":"2006-01-09T16:20:38Z","timestamp":1136823638000},"page":"182-191","source":"Crossref","is-referenced-by-count":73,"title":["Determinants of the Quality of Life in Alzheimer\u2019s Disease Patients as Assessed by the Japanese Version of the Quality of Life \u2013 Alzheimer\u2019s Disease Scale"],"prefix":"10.1159","volume":"21","author":[{"given":"Teruo","family":"Matsui","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shutaro","family":"Nakaaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshie","family":"Murata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junko","family":"Sato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiro","family":"Shinagawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Tatsumi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiaki A.","family":"Furukawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2006,2,6]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1023%2FA%3A1012522013817"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1097%2F00002093-200310000-00002"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002%2Fgps.355"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2F0022-3956%2875%2990026-6"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1177%2F135910457000100301"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1159%2F000017236"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1159%2F000017113"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1159%2F000067972"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1159%2F000074277"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1176%2Fappi.ajgp.11.2.214"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1532-5415.2001.49210.x"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1176%2Fappi.ajgp.12.3.272"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1002%2Fgps.1075"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1159%2F000076354"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1159%2F000026556"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1159%2F000079196"}],"container-title":["Dementia and Geriatric Cognitive Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/90744","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/90744","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:47:35Z","timestamp":1745462855000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000090744"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006]]},"references-count":16,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2006,2,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000090744","archive":["Portico"],"relation":{},"ISSN":["1420-8008","1421-9824"],"issn-type":[{"value":"1420-8008","type":"print"},{"value":"1421-9824","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006]]}}}