{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T01:39:08Z","timestamp":1791164348090,"version":"4.1.0"},"reference-count":27,"publisher":"S. Karger AG","issue":"1-2","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dev Neurosci"],"published-print":{"date-parts":[[2006]]},"abstract":"<jats:p>The basic helix-loop-helix genes &lt;i&gt;Hes1&lt;\/i&gt; and &lt;i&gt;Hes5,&lt;\/i&gt; known Notch effectors, regulate the maintenance of neural stem cells and the development of the central nervous system (CNS). In the absence of &lt;i&gt;Hes1&lt;\/i&gt; and &lt;i&gt;Hes5,&lt;\/i&gt; the size, shape and cytoarchitecture of the CNS are severely disorganized, but the development of the peripheral nervous system remains to be analyzed. Here, we found that in &lt;i&gt;Hes1;Hes5&lt;\/i&gt; double-mutant mice, the cranial and spinal nerve systems are also severely disorganized. In these mutant mice, axonal projections from the mesencephalic neurons to the trigeminal (V) ganglion become aberrant and the proximal parts of the glossopharyngeal (IX) and vagus (X) nerves are fused. The hypoglossal (XII) nerve is also formed poorly. Furthermore, the dorsal root ganglia are fused with the spinal cord, and the dorsal and ventral roots of the spinal nerves are lacking in many segments. These results indicate that &lt;i&gt;Hes1&lt;\/i&gt; and &lt;i&gt;Hes5&lt;\/i&gt; play an important role in the formation of the cranial and spinal nerve systems.<\/jats:p>","DOI":"10.1159\/000090756","type":"journal-article","created":{"date-parts":[[2006,3,1]],"date-time":"2006-03-01T10:08:13Z","timestamp":1141207693000},"page":"92-101","source":"Crossref","is-referenced-by-count":48,"title":["&lt;i&gt;Hes1 &lt;\/i&gt;and &lt;i&gt;Hes5&lt;\/i&gt; Regulate the Development of the Cranial and Spinal Nerve Systems"],"prefix":"10.1159","volume":"28","author":[{"given":"Jun","family":"Hatakeyama","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susumu","family":"Sakamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryoichiro","family":"Kageyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2006,3,3]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1126%2Fscience.1062028"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.94.10.5355"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1038%2F35090039"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2FS0896-6273%2800%2980989-7"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2FS0896-6273%2800%2981172-1"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1006%2Fmcne.1997.0647"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1242%2Fdev.01436"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1093%2Femboj%2F20.16.4454"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2443.1996.10010.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1006%2Fdbio.1996.8501"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1101%2Fgad.9.24.3136"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1038%2F377355a0"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2FS0959-437X%2897%2980014-7"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1523%2FJNEUROSCI.5327-03.2004"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1006%2Fgeno.1998.5213"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1093%2Femboj%2F18.8.2196"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1074%2Fjbc.M102420200"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1006%2Fmcne.1999.0826"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1002%2Fcne.10254"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1101%2Fgad.6.12b.2620"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016%2F0092-8674%2893%2990329-O"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1146%2Fannurev.neuro.26.041002.131334"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016%2F0896-6273%2895%2990005-5"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1038%2F384630a0"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1101%2Fgad.7.11.2071"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016%2FS0896-6273%2802%2901188-1"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1006%2Fdbio.2001.0447"}],"container-title":["Developmental Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/90756","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/90756","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:47:43Z","timestamp":1745462863000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000090756"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006]]},"references-count":27,"journal-issue":{"issue":"1-2","published-online":{"date-parts":[[2006,2,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000090756","archive":["Portico"],"relation":{},"ISSN":["0378-5866","1421-9859"],"issn-type":[{"value":"0378-5866","type":"print"},{"value":"1421-9859","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006]]}}}