{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T10:36:23Z","timestamp":1788863783889,"version":"build-2803163510"},"reference-count":13,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Nephrol"],"published-print":{"date-parts":[[2006]]},"abstract":"<i>Background:<\/i> We studied whether the measurement of intrarenal vascular resistance by Doppler ultrasonography, capable of investigating renal interstitial compartment, allows the early detection of chronic tubulointerstitial nephropathy (TIN). <i>Methods:<\/i> 30 normotensive and 28 hypertensive (I-II OMS) patients with a clinical history suggestive of chronic TIN and normal renal function were enrolled. 40 healthy volunteers served as controls. Patients were considered TIN-negative or TIN-positive after investigating tubular function by urine concentrating and acidification tests. Renal sonographic parameters and renal resistive index (RRI) were obtained by duplex scanner. Glomerular filtration rate\/effective renal plasmatic flow ratio was investigated by sequential renal scintigraphy in TIN-negative and TIN-positive patients; <sup>99m<\/sup>Tc-DMSA scintigraphy was also performed in TIN-positive patients. <i>Results:<\/i> RRI values of TIN-positive normotensive and hypertensive patients were significantly higher (p < 0.01 for both) than those of TIN-negative patients and of controls. RRI values resulted to be linearly related to uricemia (r = 0.88, p < 0.0001) only in normotensive patients. RRI values also resulted to be linearly related to filtration ratio values (r = 0.60, p < 0.0001). <sup>99m<\/sup>Tc-DMSA scintigraphy confirmed interstitial renal damage (grade 1 and 2). <i>Conclusion:<\/i> RRI measurement allows the early identification of both normotensive and hypertensive patients with chronic TIN and signs of tubular dysfunction, when renal function is still preserved.<\/jats:p>","DOI":"10.1159\/000090786","type":"journal-article","created":{"date-parts":[[2006,1,6]],"date-time":"2006-01-06T10:43:21Z","timestamp":1136544201000},"page":"16-21","source":"Crossref","is-referenced-by-count":48,"title":["Renal Resistive Index Early Detects Chronic Tubulointerstitial Nephropathy in Normo- and Hypertensive Patients"],"prefix":"10.1159","volume":"26","author":[{"given":"Maria","family":"Boddi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilaria","family":"Cecioni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Loredana","family":"Poggesi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Fiorentino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katia","family":"Olianti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabino","family":"Berardino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"La Cava","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"GianFranco","family":"Gensini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2006,4,5]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1523-1755.1998.00001.x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.semnephrol.2004.10.001"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1161%2Fhy0202.103782"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1159%2F000130554"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1523-1755.2005.00230.x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2F0895-7061%2896%2900027-1"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1093%2Fndt%2F14.2.360"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMra011078"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1291%2Fhypres.24.691"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1523-1755.2005.00074.x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1093%2Fndt%2Fgfh584"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1038%2Fki.1990.266"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291097-0096%28200002%2928%3A2%3C73%3A%3AAID-JCU3%3E3.0.CO%3B2-E"}],"container-title":["American Journal of Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/90786","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/90786","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:47:49Z","timestamp":1745462869000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000090786"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006]]},"references-count":13,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2006,4,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000090786","archive":["Portico"],"relation":{},"ISSN":["0250-8095","1421-9670"],"issn-type":[{"value":"0250-8095","type":"print"},{"value":"1421-9670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006]]}}}