{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T13:35:49Z","timestamp":1762954549607,"version":"3.40.4"},"reference-count":4,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Urol Int"],"published-print":{"date-parts":[[2006]]},"abstract":"<jats:p>&lt;i&gt;Objective:&lt;\/i&gt; The efficacy and safety of using \u03b1&lt;sub&gt;1&lt;\/sub&gt;-adrenergic blockers for treating primary bladder neck obstruction in young and middle-aged men was assessed as the first therapeutic step, before surgery, in a symptomatic non-neurogenic selected group of patients. &lt;i&gt;Materials and Methods:&lt;\/i&gt; From January 1995 to December 2001, primary bladder neck obstruction was diagnosed in 41 men whose average age was 43 years. All of them were evaluated by a complete clinical history, American Urological Association (AUA) symptom score index, physical examination, uroflowmetry, transabdominal ultrasound prostatic volume determination, ultrasound post-void residual determination, videourodynamics including pressure-flow analysis and upper urinary tract screening with renal ultrasound or an excretory urogram. A full daily dose of \u03b1&lt;sub&gt;1&lt;\/sub&gt;-adrenergic blockers (alfuzosin or tamsulosin) was administered for at least 6 months. Successful treatment was defined as improved symptoms, voiding diary, maximum flow rate and pressure-flow parameters. Patients who did not gain improvement of symptoms with pharmacological treatment were offered surgery. &lt;i&gt;Results:&lt;\/i&gt; Overall, pharmacological treatment was successful in 29\/41 patients (70.7%) whereas bladder neck endoscopic incision was mandatory in 12\/41 (29.3%). &lt;i&gt;Conclusions:&lt;\/i&gt; \u03b1&lt;sub&gt;1&lt;\/sub&gt;-Blockers were effective and safe for treating young and middle-aged men with symptomatic bladder neck obstruction.<\/jats:p>","DOI":"10.1159\/000090879","type":"journal-article","created":{"date-parts":[[2006,2,22]],"date-time":"2006-02-22T11:46:38Z","timestamp":1140608798000},"page":"150-153","source":"Crossref","is-referenced-by-count":15,"title":["Obstructive Primary Bladder Neck Disease: Evaluation of the Efficacy and Safety of \u03b1&lt;sub&gt;1&lt;\/sub&gt;-Blockers"],"prefix":"10.1159","volume":"76","author":[{"given":"A.","family":"Cisternino","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Zeccolini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Calpista","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"De Marco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Prayer Galetti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Iafrate","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Artibani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2006,2,24]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2FS0022-5347%2805%2964682-4"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1097%2F00005392-200207000-00030"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2FS0022-5347%2801%2965605-2"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1464-410x.2000.00418.x"}],"container-title":["Urologia Internationalis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/90879","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/90879","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:48:48Z","timestamp":1745462928000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000090879"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006]]},"references-count":4,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2006,2,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000090879","archive":["Portico"],"relation":{},"ISSN":["0042-1138","1423-0399"],"issn-type":[{"type":"print","value":"0042-1138"},{"type":"electronic","value":"1423-0399"}],"subject":[],"published":{"date-parts":[[2006]]}}}