{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:10:03Z","timestamp":1745464203393,"version":"3.40.4"},"reference-count":4,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med Princ Pract"],"published-print":{"date-parts":[[2006]]},"abstract":"<i>Objective:<\/i> To present the first documented case of acute infectious gastroenteritis caused by high-level ceftriaxone-resistant <i>Salmonella enterica <\/i>serotype<i> typhimurium <\/i>in Kuwait. <i>Subject and Methods:<\/i> Isolation from stool specimen and species identification of current enteric pathogen was carried out according to standard methods. Susceptibility to antibiotics was determined by the disc diffusion method on Mueller-Hinton agar. Minimal inhibitory concentrations (MICs) were measured with E-test strips. The production of extended spectrum beta-lactamase (ESBL<i>)<\/i> was studied by the double disc synergy method and E-test ESBL strips. Plasmid DNA isolation was performed by the rapid alkaline lysis method. Plasmid DNA was transferred by conjugation to a recipient strain of <i>Escherichia coli<\/i>. <i>Results:<\/i> The isolate of <i>S. enterica<\/i> serotype <i>typhimurium<\/i> was resistant to ceftriaxone (MIC >256 mg\/l), cefotaxime and ceftazidime, and produced ESBL. Ceftriaxone and cefotaxime resistance were co-transferred on a 3.2-kb plasmid to the <i>E. coli<\/i> recipient strain. Loss of the 3.2-kb plasmid from the transconjugant resulted in the co-loss of ceftriaxone and cefotaxime resistance confirming the carriage of ceftriazone resistance on the 3.2-kb plasmid. <i>Conclusion:<\/i> Plasmid-mediated high-level resistance to ceftriaxone and ESBL production in <i>Salmonella<\/i> serotype <i>typhimurium<\/i> is an emerging problem among <i>Salmonella<\/i> that requires closer monitoring of antimicrobial resistance among these bacterial species.<\/jats:p>","DOI":"10.1159\/000090920","type":"journal-article","created":{"date-parts":[[2006,2,15]],"date-time":"2006-02-15T11:37:29Z","timestamp":1140003449000},"page":"145-148","source":"Crossref","is-referenced-by-count":1,"title":["Plasmid-Mediated High-Level Ceftriaxone Resistance in a <i>Salmonella enterica<\/i> Serotype <i>typhimurium<\/i> Isolate"],"prefix":"10.1159","volume":"15","author":[{"given":"T.S.","family":"Dimitrov","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.E.","family":"Udo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Verghese","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Emara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alla","family":"Al-Saleh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2006,2,16]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1097%2F00006454-199302000-00007"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1097%2F00006454-199709000-00015"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1093%2Fjac%2F46.5.860"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM200004273421703"}],"container-title":["Medical Principles and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/90920","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/90920","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:49:23Z","timestamp":1745462963000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000090920"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006]]},"references-count":4,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2006,2,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000090920","archive":["Portico"],"relation":{},"ISSN":["1011-7571","1423-0151"],"issn-type":[{"type":"print","value":"1011-7571"},{"type":"electronic","value":"1423-0151"}],"subject":[],"published":{"date-parts":[[2006]]}}}