{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:10:01Z","timestamp":1745464201887,"version":"3.40.4"},"reference-count":20,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Vasc Res"],"published-print":{"date-parts":[[2006]]},"abstract":"<jats:p>We have recently reported an alternative cell therapy approach to induce angiogenesis. The approach is based on small organ fragments \u2013 micro-organs (MOs) \u2013 whose geometry allows preservation of the natural epithelial\/mesenchymal interactions and ensures appropriate diffusion of nutrients and gases to all cells. We have shown that lung-derived MOs, when implanted into hosts, transcribe a wide spectrum array of angiogenic factors and can induce an angiogenic response that can rescue experimentally induced ischemic regions in mice.From a clinical perspective, skin-derived MOs are particularly appealing as they could readily be obtained from a skin biopsy taken from the same target patient. In the present work we have investigated the angiogenesis-inducing capacity of rabbit and human skin-derived micro-organs in vitro and in vivo. Rabbit skin MOs were implanted into homologous adult rabbits and human skin MOs were encapsulated and implanted into xenogenic mice. Skin-derived MOs, as lung-derived MOs, were found to secrete a whole array of angiogenic factors and to induce a powerful angiogenic response when implanted back into animals. We believe the approach presented suggests a novel, efficacious and simple approach for therapeutic angiogenesis.<\/jats:p>","DOI":"10.1159\/000090943","type":"journal-article","created":{"date-parts":[[2006,1,12]],"date-time":"2006-01-12T13:27:51Z","timestamp":1137072471000},"page":"139-148","source":"Crossref","is-referenced-by-count":14,"title":["Skin-Derived Micro-Organs Induce Angiogenesis in Rabbits"],"prefix":"10.1159","volume":"43","author":[{"given":"Eilat","family":"Hasson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeniffer","family":"Gallula","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yael","family":"Shimoni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Etty","family":"Grad-Itach","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moshe","family":"Marikovsky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo","family":"Mitrani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2006,2,16]]},"reference":[{"doi-asserted-by":"publisher","key":"ref1","DOI":"10.1159%2F000075994"},{"doi-asserted-by":"publisher","key":"ref2","DOI":"10.1177%2F00912700122010230"},{"doi-asserted-by":"publisher","key":"ref3","DOI":"10.1080%2F08977190412331284344"},{"doi-asserted-by":"publisher","key":"ref4","DOI":"10.1172%2FJCI6889"},{"doi-asserted-by":"publisher","key":"ref5","DOI":"10.1038%2F80430"},{"doi-asserted-by":"publisher","key":"ref6","DOI":"10.1038%2F70928"},{"doi-asserted-by":"publisher","key":"ref7","DOI":"10.1038%2F35025215"},{"doi-asserted-by":"publisher","key":"ref8","DOI":"10.1089%2F15258160260194721"},{"doi-asserted-by":"publisher","key":"ref9","DOI":"10.1089%2F152581602753658385"},{"doi-asserted-by":"publisher","key":"ref10","DOI":"10.1152%2Fajpcell.00330.2003"},{"doi-asserted-by":"publisher","key":"ref11","DOI":"10.1159%2F000082897"},{"doi-asserted-by":"publisher","key":"ref12","DOI":"10.1002%2Fjgm.740"},{"doi-asserted-by":"publisher","key":"ref13","DOI":"10.1111%2Fj.1432-0436.2005.07302002.x"},{"doi-asserted-by":"publisher","key":"ref14","DOI":"10.1017%2FS0958067099018527"},{"doi-asserted-by":"publisher","key":"ref15","DOI":"10.1067%2Fmhj.2001.118471"},{"doi-asserted-by":"publisher","key":"ref16","DOI":"10.1038%2Fnbt1101-1029"},{"doi-asserted-by":"publisher","key":"ref17","DOI":"10.1038%2F329630a0"},{"doi-asserted-by":"publisher","key":"ref18","DOI":"10.1089%2F1043034041361172"},{"doi-asserted-by":"publisher","key":"ref19","DOI":"10.1016%2Fj.jhep.2004.08.016"},{"doi-asserted-by":"publisher","key":"ref20","DOI":"10.1006%2Fmthe.2002.0646"}],"container-title":["Journal of Vascular Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/90943","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/90943","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:49:40Z","timestamp":1745462980000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000090943"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006]]},"references-count":20,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2006,2,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000090943","archive":["Portico"],"relation":{},"ISSN":["1018-1172","1423-0135"],"issn-type":[{"type":"print","value":"1018-1172"},{"type":"electronic","value":"1423-0135"}],"subject":[],"published":{"date-parts":[[2006]]}}}