{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T10:34:46Z","timestamp":1756895686109,"version":"3.40.4"},"reference-count":22,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gerontology"],"published-print":{"date-parts":[[2006]]},"abstract":"<i>Background:<\/i> The effect of <i>Helicobacter pylori<\/i> eradication on the clinical outcome of esophagitis in elderly patients is controversial. <i>Aim:<\/i> To evaluate the effect of <i>H. pylori<\/i> eradication on clinical outcome of esophagitis and on chronic gastritis and its activity. <i>Materials and Methods:<\/i> Sixty-one symptomatic elderly patients with esophagitis and <i>H. pylori<\/i> infection were randomized into two groups. Group 1 (PPI-only, 30 patients) was treated with pantoprazole 40 mg daily for 2 months followed by pantoprazole 20 mg daily for a further 6 months; group 2 (PPI + eradication, 31 patients) was treated as group 1 plus a 1-week course of amoxicillin 1 g twice daily and clarithromycin 250 mg twice daily. Endoscopy with gastric biopsies, <sup>13<\/sup>C-UBT and clinical visits were repeated after 2 and 8 months. <i>Results:<\/i> After 8 months, the intention-to-treat <i>H. pylori<\/i> eradication rates were 19.2% in group 1 vs. 80.7% in group 2 (p < 0.0001). No differences between group 1 and group 2 were observed in symptoms improvement (77 vs. 77%, p = n.s.) and healing rates of esophagitis (92.3 vs. 88.5%, p = n.s.). A significant decrease in the prevalence of moderate\/severe chronic gastritis (from 52.2 to 4.7%, p = 0.002) and its activity (from 38 to 4.7%, p = 0.02) was observed in the antrum of patients of group 2, and not in patients of group 1. While a nonsignificant reduction in the chronic gastritis activity (from 28.6 to 4.7%, p = 0.09) was observed in the corpus of the eradicated patients of group 2, conversely a significant worsening of the chronic gastritis activity was found in the corpus of group 1 patients (from 25 to 60%, p = 0.05). <i>Conclusion:<\/i> The eradication of <i>H. pylori<\/i> infection does not affect the clinical outcome of esophagitis, while it improves chronic gastritis and its activity in elderly patients on short- and long-term treatment with PPIs. These findings suggest that <i>H. pylori<\/i> infection should be eradicated in elderly patients with esophagitis who need maintenance treatment with PPI.<\/jats:p>","DOI":"10.1159\/000090955","type":"journal-article","created":{"date-parts":[[2006,3,1]],"date-time":"2006-03-01T10:08:13Z","timestamp":1141207693000},"page":"99-106","source":"Crossref","is-referenced-by-count":17,"title":["Effect of <i>Helicobacter pylori<\/i> Eradication on the Outcome of Reflux Esophagitis and Chronic Gastritis in the Elderly"],"prefix":"10.1159","volume":"52","author":[{"given":"Alberto","family":"Pilotto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Perri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gioacchino","family":"Leandro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marilisa","family":"Franceschi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2006,2,28]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.bpg.2004.06.015"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2036.2004.02172.x"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1136%2Fpgmj.72.846.221"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1523-5378.2000.00003.x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2FS1590-8658%2802%2980125-6"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2036.1999.00544.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1097%2F01.mcg.0000139071.30956.30"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1053%2Fgast.2001.29332"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1136%2Fgut.53.1.12"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.3109%2F00365528609034617"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2036.2003.01593.x"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2036.2002.01226.x"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1023%2FA%3A1010616710501"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2800%2904894-7"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1097%2F00004836-199801000-00006"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.humpath.2004.12.008"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1440-1746.2003.03301.x"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1136%2Fbmj.326.7392.737"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1440-1746.2000.02131.x"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMoa001999"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016%2FS0016-5085%2800%2970410-0"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1053%2Fgast.2000.8550"}],"container-title":["Gerontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/90955","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/90955","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:49:51Z","timestamp":1745462991000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000090955"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006]]},"references-count":22,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2006,2,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000090955","archive":["Portico"],"relation":{},"ISSN":["0304-324X","1423-0003"],"issn-type":[{"type":"print","value":"0304-324X"},{"type":"electronic","value":"1423-0003"}],"subject":[],"published":{"date-parts":[[2006]]}}}