{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T03:13:15Z","timestamp":1777518795448,"version":"3.51.4"},"reference-count":8,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dement Geriatr Cogn Disord"],"published-print":{"date-parts":[[2006]]},"abstract":"<jats:p>Aberrant phosphorylated tau is the major component of the neurofibrillary tangles in Alzheimer\u2019s disease (AD) brains. Glycogen synthase kinase-3\u03b2 (GSK-3\u03b2) phosphorylates tau protein, and increased GSK-3\u03b2 expression has been associated with neurofibrillary tangles. Saitohin (STH) is a recently identified protein that shares tissue expression pattern with tau, and previous evidence in the Spanish population indicated that a polymorphism at codon 7 (Q7R) of the STH gene was associated with late-onset AD. Since both GSK-3\u03b2 and STH are related to tau, we examined the association between a polymorphism in the promoter region (\u201350) of the GSK-3\u03b2 gene and AD, either through an independent effect or through interaction with the STH (Q7R) polymorphism, in a well-defined group of 333 sporadic AD patients and 307 control subjects from Spain. The current study reveals that GSK-3\u03b2 (\u201350) TT genotype is associated with an increased risk (OR 1.99, p = 0.003) for late-onset (after the age of 72 years) AD. Our results indicate that both the GSK-3\u03b2 (\u201350) and STH (Q7R) polymorphisms increase the risk of late-onset (subjects &gt;72 years) AD, although they appear to be independent and thus not to interact synergistically.<\/jats:p>","DOI":"10.1159\/000091044","type":"journal-article","created":{"date-parts":[[2006,1,19]],"date-time":"2006-01-19T09:39:01Z","timestamp":1137663541000},"page":"228-232","source":"Crossref","is-referenced-by-count":45,"title":["Association between Glycogen Synthase Kinase-3\u03b2 Genetic Polymorphism and Late-Onset Alzheimer\u2019s Disease"],"prefix":"10.1159","volume":"21","author":[{"given":"Ignacio","family":"Mateo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jon","family":"Infante","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier","family":"Llorca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eloy","family":"Rodr\u00edguez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9","family":"Berciano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Onofre","family":"Combarros","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2006,4,7]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1093%2Femboj%2F20.1.27"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.mp.4000852"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1074%2Fjbc.M311512200"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.nbd.2003.12.009"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1093%2Fhmg%2Fddi241"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.112194599"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1159%2F000071000"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1006%2Fgeno.1999.5875"}],"container-title":["Dementia and Geriatric Cognitive Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/91044","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/91044","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:50:38Z","timestamp":1745463038000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000091044"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006]]},"references-count":8,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2006,4,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000091044","archive":["Portico"],"relation":{},"ISSN":["1420-8008","1421-9824"],"issn-type":[{"value":"1420-8008","type":"print"},{"value":"1421-9824","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006]]}}}